| dc.contributor.advisor | Eswarappa, Sandeep | |
| dc.contributor.author | Kumar, Sangeetha Devi | |
| dc.date.accessioned | 2024-01-02T05:40:11Z | |
| dc.date.available | 2024-01-02T05:40:11Z | |
| dc.date.submitted | 2023 | |
| dc.identifier.uri | https://etd.iisc.ac.in/handle/2005/6342 | |
| dc.description.abstract | Erythrocytes are specialized cells that perform the crucial function of gas exchange in all
vertebrates. Regulation of gene expression was believed to be absent in these cells due
to the absence of nucleus. It was also assumed that ribosomes are removed during their
maturation and hence they cannot synthesize proteins. But these cells perform various
metabolic processes and require these enzymes to be replenished. The oxygen carrier,
hemoglobin, also needs to be supplied constantly for these cells to carry out their
function. This thesis provides evidence for low-level translation in human erythrocytes.
The regulation of translation and its physiological significance is also explained. Methods
to modulate translation using antisense oligonucleotides (ASOs) are described. Lastly,
the evolutionary significance of a-globin gene duplication in mammals in discussed. | en_US |
| dc.language.iso | en_US | en_US |
| dc.relation.ispartofseries | ;ET00354 | |
| dc.rights | I grant Indian Institute of Science the right to archive and to make available my thesis or dissertation in whole or in part in all forms of media, now hereafter known. I retain all proprietary rights, such as patent rights. I also retain the right to use in future works (such as articles or books) all or part
of this thesis or dissertation | en_US |
| dc.subject.classification | Research Subject Categories::NATURAL SCIENCES::Chemistry::Biochemistry | en_US |
| dc.title | Translation in Erythroid cells | en_US |
| dc.type | Thesis | en_US |
| dc.degree.name | PhD | en_US |
| dc.degree.level | Doctoral | en_US |
| dc.degree.grantor | Indian Institute of Science | en_US |
| dc.degree.discipline | Faculty of Science | en_US |
