| dc.contributor.advisor | Nagaraju, Ganesh | |
| dc.contributor.author | Saxena, Sneha | |
| dc.date.accessioned | 2022-01-11T04:34:27Z | |
| dc.date.available | 2022-01-11T04:34:27Z | |
| dc.date.submitted | 2019 | |
| dc.identifier.uri | https://etd.iisc.ac.in/handle/2005/5588 | |
| dc.description.abstract | The focus of my research has been to understand the molecular mechanisms underlying
the role of mammalian RAD51 paralogs in genome maintenance and tumor suppression. The
investigation carried out during this study has contributed to identify unanticipated functions
of these genome caretakers in the cellular response to replication stress and accompanying
repair mechanisms. These include maintenance of cellular nucleotide pools through the
regulation of ribonucleotide reductase (RNR), modulation of replication fork progression
during nucleotide pool alterations and protection of stressed forks to foster genome integrity
during perturbed DNA replication. Moreover, my study has uncovered an ATR signaling
governed functional interplay between RAD51 paralogs, where distinct paralog complexes
collaboratively facilitate genome integrity and cell survival during replication stress | en_US |
| dc.language.iso | en_US | en_US |
| dc.rights | I grant Indian Institute of Science the right to archive and to make available my thesis or dissertation in whole or in part in all forms of media, now hereafter known. I retain all proprietary rights, such as patent rights. I also retain the right to use in future works (such as articles or books) all or part
of this thesis or dissertation | en_US |
| dc.subject | molecular mechanisms | en_US |
| dc.subject | RAD51 paralogs | en_US |
| dc.subject | genome caretakers | en_US |
| dc.subject | ribonucleotide reductase | en_US |
| dc.subject.classification | Research Subject Categories::NATURAL SCIENCES::Chemistry::Biochemistry | en_US |
| dc.title | Role of mammalian RAD51 paralogs in replication stress response and genome maintenance | en_US |
| dc.type | Thesis | en_US |
| dc.degree.name | PhD | en_US |
| dc.degree.level | Doctoral | en_US |
| dc.degree.grantor | Indian Institute of Science | en_US |
| dc.degree.discipline | Faculty of Science | en_US |
