| dc.contributor.advisor | Rangarajan, Annapoorni | |
| dc.contributor.author | Kumar, Saurav | |
| dc.date.accessioned | 2021-10-20T07:23:39Z | |
| dc.date.available | 2021-10-20T07:23:39Z | |
| dc.date.submitted | 2018 | |
| dc.identifier.uri | https://etd.iisc.ac.in/handle/2005/5442 | |
| dc.description.abstract | Our study identifies negative cross-talk between AMPK and two important cellular kinases, Akt and Erk. AMPK-mediated inhibition of these two kinases promotes survival of cancer cells in the matrix-deprived condition. Activated AMPK leads to upregulation of several metabolic changes needed for the conservation of energy. Collectively, AMPK activation, in the context of matrix deprivation, promotes cell survival by effecting multiple nodes of cell signaling and metabolic pathways. Thus, inhibition of AMPK would be an effective way to compromise cell survival in matrix deprivation, thereby reducing the metastatic spread of cancer | en_US |
| dc.language.iso | en_US | en_US |
| dc.relation.ispartofseries | ;G29279 | |
| dc.rights | I grant Indian Institute of Science the right to archive and to make available my thesis or dissertation in whole or in part in all forms of media, now hereafter known. I retain all proprietary rights, such as patent rights. I also retain the right to use in future works (such as articles or books) all or part
of this thesis or dissertation | en_US |
| dc.subject | AMP-activated protein kinase | en_US |
| dc.subject | breast cancer cells | en_US |
| dc.subject | Akt | en_US |
| dc.subject | Erk | en_US |
| dc.subject | Cancer cells | en_US |
| dc.subject.classification | Research Subject Categories::NATURAL SCIENCES::Biology::Cell and molecular biology | en_US |
| dc.title | Molecular insights into AMP-activated protein kinase (AMPK)-mediated regulation of anoikis resistance | en_US |
| dc.type | Thesis | en_US |
| dc.degree.name | PhD | en_US |
| dc.degree.level | Doctoral | en_US |
| dc.degree.grantor | Indian Institute of Science | en_US |
| dc.degree.discipline | Faculty of Science | en_US |
