| dc.contributor.advisor | Rangarajan, P N | |
| dc.contributor.author | Khatun, Jesminara | |
| dc.date.accessioned | 2021-03-26T05:37:37Z | |
| dc.date.available | 2021-03-26T05:37:37Z | |
| dc.date.submitted | 2019 | |
| dc.identifier.uri | https://etd.iisc.ac.in/handle/2005/5003 | |
| dc.description.abstract | Our work demonstrates for the first time that PpRtgXp, a basic, helix-loop-helix (bHLH) protein, is a global regulator of carbon metabolism. PpRtgXp constitutively localizes inside the nucleus. Despite lacking the C-terminal leucine zipper heterodimerization domain, this bHLH protein evolved into a unique regulator of multiple metabolic pathways of P. pastoris. This is the first report on a bHLH protein functioning as a global transcriptional regulator in P. pastoris as previous studies have focussed primarily on zinc finger transcription factors such as Mxr1p, Trm1p, and Rop1p | en_US |
| dc.language.iso | en_US | en_US |
| dc.relation.ispartofseries | ;G29804 | |
| dc.rights | I grant Indian Institute of Science the right to archive and to make available my thesis or dissertation in whole or in part in all forms of media, now hereafter known. I retain all proprietary rights, such as patent rights. I also retain the right to use in future works (such as articles or books) all or part
of this thesis or dissertation | en_US |
| dc.subject | carbon metabolism | en_US |
| dc.subject | PpRtgXp | en_US |
| dc.subject | cytosol | en_US |
| dc.subject | gene | en_US |
| dc.subject.classification | Research Subject Categories::NATURAL SCIENCES::Biology::Other biology | en_US |
| dc.title | Comparative evaluation of retrograde regulatory proteins (Rtg1p, Rtg2p, and Rtg3p) of Saccharomyces cerevisiae and Pichia pastoris and identification of P. pastoris RtgXp as a novel regulator of multiple metabolic pathways | en_US |
| dc.type | Thesis | en_US |
| dc.degree.name | PhD | en_US |
| dc.degree.level | Doctoral | en_US |
| dc.degree.grantor | Indian Institute of Science | en_US |
| dc.degree.discipline | Faculty of Science | en_US |
