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Molecular Dynamics simulations reveal the role of membrane cholesterol in the pore forming pathway of Cytolysin A
We investigate the interactions of pore-forming toxins (PFTs) with cholesterol-rich
membranes through atomistic molecular dynamics simulations. The PFT of interest
is Cytolysin A (ClyA or HlyE). Cytolysin A (ClyA), an ...
Investigating Membrane Dynamics And Oligomerization Of Pore-forming Toxins Using Single-molecule Fluorescence Techniques
The biological membrane is a thin fluidic matrix composed of a lipid bilayer that forms the
primary cellular barrier against the extracellular environment. The high-density of embedded
proteins and glycosylated molecules ...