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dc.contributor.advisorMadras, Giridhar
dc.contributor.authorNatarajan, Janeni
dc.date.accessioned2018-06-29T07:52:34Z
dc.date.accessioned2018-07-31T06:39:02Z
dc.date.available2018-06-29T07:52:34Z
dc.date.available2018-07-31T06:39:02Z
dc.date.issued2018-06-29
dc.date.submitted2017
dc.identifier.urihttps://etd.iisc.ac.in/handle/2005/3776
dc.identifier.abstracthttp://etd.iisc.ac.in/static/etd/abstracts/4647/G28515-Abs.pdfen_US
dc.description.abstractRegeneration, a spontaneous response of bones in response to injuries, infections and fractures, is severely compromised in certain clinical circumstances. Unfortunately, several shortcomings are associated with the current treatment of bone grafting method such as donor shortage and immune response for allografts and donor morbidity for autografts. Thus, the development of clinical alternates is essential. One promising adjunct method is bone tissue engineering that includes the implantation of a scaffold containing the cells with the supplementation of suitable growth factors. Among the various classes of materials, biodegradable polymers are commonly preferred because their use does not necessitate a secondary surgery for their removal after the intended use. Commercially available polymers such as poly (lactic- co- glycolic acid) and polycaprolactone are expensive and degrade slowly. This motivates the development of novel synthetic biodegradable polymers that are affordable and can be tuned to tailor for specific biomedical applications. The primary aim of this thesis is to synthesize effective biodegradable polymers for drug delivery and bone tissue engineering. The properties of these polymers such as modulus, hydrophobicity and crosslinking etc. were tailored based on the variations in chemical bonds, chain lengths and the molar stoichiometric ratios of the monomers for specific clinical applications. Based on the above variations, degradation and release kinetics were tuned. The cytocompatibilty properties for these polymers were studied and suitable mineralization studies were conducted to determine their potential for bone regeneration.en_US
dc.language.isoen_USen_US
dc.relation.ispartofseriesG28515en_US
dc.subjectDrug Deliveryen_US
dc.subjectBiodegradable Polymersen_US
dc.subjectTissue Engineeringen_US
dc.subjectPoly (ethylene erephthalate)en_US
dc.subjectCastor Oil Sebacic Aciden_US
dc.subjectBiodegradable Polymersen_US
dc.subjectPolyanhydridesen_US
dc.subjectMaltitolen_US
dc.subjectGalactitol Polyester Elastomersen_US
dc.subjectPoly (ester amide)sen_US
dc.subjectEpoxidized Soybean Oil (ESO)en_US
dc.subjectPoly (Galactitol Sebacate)en_US
dc.subjectBone Tissue Engineeringen_US
dc.subjectGalactitolen_US
dc.subject.classificationNanoscienceen_US
dc.titleBiodegradable Polymers for Drug Delivery and Tissue Engineeringen_US
dc.typeThesisen_US
dc.degree.namePhDen_US
dc.degree.levelDoctoralen_US
dc.degree.disciplineFaculty of Engineeringen_US


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