Tuberculosis (TB) is a debilitating infectious disease that afflicts 10 million people every year. Treatment is particularly challenging due to prolonged treatment duration (4-6 months) consisting of an oral regimen of 4 ...

Pseudomonas aeruginosa is a Gram-negative opportunistic pathogen, estimated to account for 15-20% of hospital-acquired infection-related deaths around the globe in a year. This bacterium exhibits two distinct collective ...

Mechanosensors play a vital role in how cells respond to external forces, impacting cell-substrate adhesions through integrin clustering and focal adhesion formation associated with actomyosin contractility. Adhesions ...

Biological processes are inherently noisy, and such stochasticity can result in significant cell to cell variability in isogenic bacterial populations. Functionally, cellular heterogeneity can have significant impact on ...

Breast cancer currently accounts for 25% of all cancers diagnosed in women globally. The conventional confirmatory diagnosis of breast cancer involves histological analysis using hematoxylin and eosin (H&E) staining, ...

Medical implants include products that are used to replace or restore the function of any damaged organ or tissue inside the body. The current generation of implants are mostly made from non-degradable materials and are ...

Silicone venous catheters are among the most used medical devices in the world with a prevalence of up to 80% in hospitalised patients. While they are used for several life-saving applications, they are also prone to ...

Aging is a ubiquitous process that results in the progressive and irreversible loss of function. It is induced by accumulating damage caused by a variety of stressors, both internal and external. Although the advancement ...

Pathogens from bacterial class: Salmonella, Mycobacterium tuberculosis, Listeria can survive and replicate intracellularly. While some pathogens remain cytosolic others such as Salmonella and Mycobacterium tuberculosis ...

Biomechanics is an important regulator of cell function. Active (external forces) as well as passive (substrate stiffness) mechanical stimuli from the cell microenvironment can alter fundamental aspects of cell function ...