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Development of anti-infective therapy against intracellular pathogens using targeted particulate delivery systems
Pathogens from bacterial class: Salmonella, Mycobacterium tuberculosis, Listeria can survive and replicate intracellularly. While some pathogens remain cytosolic others such as Salmonella and Mycobacterium tuberculosis ...
Insights into signalling and crosstalk in two-component signalling systems of Mycobacterium tuberculosis
Tuberculosis (TB), caused by the pathogen Mycobacterium tuberculosis (Mtb), has very recently reclaimed the position of the leading cause of deaths in humans from a single infection agent. This suggests a dire need to ...
Investigation of cell membrane dynamics: A potential marker for lipid response towards membrane-active proteins and peptides
The cell membrane is made up of lipids and proteins held together with intermolecular hydrophobic/hydrophilic interactions. These physical non-covalent interactions help in maintaining the integrity of the cell membrane, ...
Design and Development of a Semi-automated System for Electro-thermo-mechanical (Etm) Phenotyping of Breast Tissues Ex-vivo
Breast cancer currently accounts for 25% of all cancers diagnosed in women globally. The conventional confirmatory diagnosis of breast cancer involves histological analysis using hematoxylin and eosin (H&E) staining, ...
Delineating the dynamics of neutrophil response in multiple inflammatory stimuli and its consequences
In this thesis, we investigate the regulation of neutrophils, an important component of the immune system, and its implications on inflammation and pathological conditions. We use biomaterial implants to induce chronic ...
Micro-carriers mediated bacteriophage delivery for targeting intracellular Mycobacterium tuberculosis infection and TB prevention
Tuberculosis (TB) is a debilitating infectious disease that afflicts 10 million people every year. Treatment is particularly challenging due to prolonged treatment duration (4-6 months) consisting of an oral regimen of 4 ...
Experimental and computational approaches to understand collective behaviors of bacterial pathogen Pseudomonas aeruginosa
Pseudomonas aeruginosa is a Gram-negative opportunistic pathogen, estimated to account for 15-20% of hospital-acquired infection-related deaths around the globe in a year. This bacterium exhibits two distinct collective ...
Dynamical systems biology approach to identify mediators of the Epithelial-Hybrid-Mesenchymal spectrum
Cancer metastasis – the spread of cancer cells from one organ to another – remains the major cause of cancer-related deaths. A hallmark of metastasizing cells is their ability to adapt quickly and reversibly to their dynamic ...
Design Principles of Phenotypic Robustness and Plasticity in Gene Regulatory Networks underlying Cancer Metastasis
Metastasis – the process of cancer cells leaving the primary tumor and colonizing multiple organs – remains a major cause of cancer mortality. However, it is a highly inefficient process with only 0.01% of disseminated ...
New Dimension in Senescence: Unraveling Cellular Senescence in Three-Dimensional Scaffolds
Aging is a ubiquitous process that results in the progressive and irreversible loss of
function. It is induced by accumulating damage caused by a variety of stressors, both internal
and external. Although the advancement ...