Cancer metastasis – the spread of cancer cells from one organ to another – remains the major cause of cancer-related deaths. A hallmark of metastasizing cells is their ability to adapt quickly and reversibly to their dynamic ...

Metastasis – the process of cancer cells leaving the primary tumor and colonizing multiple organs – remains a major cause of cancer mortality. However, it is a highly inefficient process with only 0.01% of disseminated ...

Tuberculosis (TB) is a debilitating infectious disease that afflicts 10 million people every year. Treatment is particularly challenging due to prolonged treatment duration (4-6 months) consisting of an oral regimen of 4 ...

Pseudomonas aeruginosa is a Gram-negative opportunistic pathogen, estimated to account for 15-20% of hospital-acquired infection-related deaths around the globe in a year. This bacterium exhibits two distinct collective ...

Cellular differentiation is controlled by the complex dynamics of gene regulatory networks (GRNs), often featuring multistability, where multiple stable states represent different phenotypes. A common example is the toggle ...

Positive-sense single-stranded RNA ((+)RNA) viruses pose significant challenges to public health. Notable families such as Enteroviridae, Flaviviridae, and Coronaviridae have caused epidemics (Dengue, Poliomyelitis, Zika) ...

Mechanosensors play a vital role in how cells respond to external forces, impacting cell-substrate adhesions through integrin clustering and focal adhesion formation associated with actomyosin contractility. Adhesions ...

Biological processes are inherently noisy, and such stochasticity can result in significant cell to cell variability in isogenic bacterial populations. Functionally, cellular heterogeneity can have significant impact on ...

Breast cancer currently accounts for 25% of all cancers diagnosed in women globally. The conventional confirmatory diagnosis of breast cancer involves histological analysis using hematoxylin and eosin (H&E) staining, ...

In this thesis, we investigate the regulation of neutrophils, an important component of the immune system, and its implications on inflammation and pathological conditions. We use biomaterial implants to induce chronic ...