Browsing Department of Bioengineering (BE, Earlier known as BSSE) by thesis submitted date"2024"
Now showing items 1-7 of 7
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4D Printing of Polymer Composites to Engineer Resorbable and Deployable Implants
Medical implants include products that are used to replace or restore the function of any damaged organ or tissue inside the body. The current generation of implants are mostly made from non-degradable materials and are ... -
Bioengineering strategies to model and modulate immune cells
Optimal activation of immune cells is necessary to elicit a protective response against pathogens and foreign objects. In dysregulated immune systems, cells are aberrantly activated or exhausted. Understanding biochemical ... -
Biophysics of focal adhesion and cytoskeletal remodeling under fluid shear
Mechanosensors play a vital role in how cells respond to external forces, impacting cell-substrate adhesions through integrin clustering and focal adhesion formation associated with actomyosin contractility. Adhesions ... -
Cues for phagosome maturation deciphered using a tuneable particulate system
Phagocytosis, an essential component of the innate immune response, is followed by the process of phagosome maturation inside the cell. Maturation ensures that the engulfed target is delivered to the acidic lysosome for ... -
Engineering three-dimensional hydrogel culture systems to delineate host-pathogen interaction in tuberculosis
Mycobacterium tuberculosis (Mtb), an obligate human pathogen, spreads through aerosols to the lung alveoli, where alveolar macrophages engulf it. These macrophages then migrate to the lung interstitium and trigger an ... -
Immune cell surveillance and death on silicone catheter surfaces drives bacterial biofilm formation
Silicone venous catheters are among the most used medical devices in the world with a prevalence of up to 80% in hospitalised patients. While they are used for several life-saving applications, they are also prone to ... -
Multistability in cellular differentiation enabled by three and four node mutually repressive regulatory networks: A case study of CD4+ T-cell decision making
Cellular differentiation is controlled by the complex dynamics of gene regulatory networks (GRNs), often featuring multistability, where multiple stable states represent different phenotypes. A common example is the toggle ...