Browsing Department of Bioengineering (BE, Earlier known as BSSE) by thesis submitted date"2023"
Now showing items 1-8 of 8
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Bacterial cellular heterogeneity in inducible gene expression and drug susceptibility
Biological processes are inherently noisy, and such stochasticity can result in significant cell to cell variability in isogenic bacterial populations. Functionally, cellular heterogeneity can have significant impact on ... -
Delineating the dynamics of neutrophil response in multiple inflammatory stimuli and its consequences
In this thesis, we investigate the regulation of neutrophils, an important component of the immune system, and its implications on inflammation and pathological conditions. We use biomaterial implants to induce chronic ... -
Design Principles of Phenotypic Robustness and Plasticity in Gene Regulatory Networks underlying Cancer Metastasis
Metastasis – the process of cancer cells leaving the primary tumor and colonizing multiple organs – remains a major cause of cancer mortality. However, it is a highly inefficient process with only 0.01% of disseminated ... -
Dynamical systems biology approach to identify mediators of the Epithelial-Hybrid-Mesenchymal spectrum
Cancer metastasis – the spread of cancer cells from one organ to another – remains the major cause of cancer-related deaths. A hallmark of metastasizing cells is their ability to adapt quickly and reversibly to their dynamic ... -
Experimental and computational approaches to understand collective behaviors of bacterial pathogen Pseudomonas aeruginosa
Pseudomonas aeruginosa is a Gram-negative opportunistic pathogen, estimated to account for 15-20% of hospital-acquired infection-related deaths around the globe in a year. This bacterium exhibits two distinct collective ... -
Integrating Computational Tools and Models to Study Positive-sense RNA Virus Lifecycle
Positive-sense single-stranded RNA ((+)RNA) viruses pose significant challenges to public health. Notable families such as Enteroviridae, Flaviviridae, and Coronaviridae have caused epidemics (Dengue, Poliomyelitis, Zika) ... -
Micro-carriers mediated bacteriophage delivery for targeting intracellular Mycobacterium tuberculosis infection and TB prevention
Tuberculosis (TB) is a debilitating infectious disease that afflicts 10 million people every year. Treatment is particularly challenging due to prolonged treatment duration (4-6 months) consisting of an oral regimen of 4 ... -
New Dimension in Senescence: Unraveling Cellular Senescence in Three-Dimensional Scaffolds
Aging is a ubiquitous process that results in the progressive and irreversible loss of function. It is induced by accumulating damage caused by a variety of stressors, both internal and external. Although the advancement ...