Biochemistry (BC): Recent submissions
Now showing items 101-120 of 250
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Structure Elucidation and Biological Evaluation of a Novel Steroidal Saponin, Cholestanol Glucoside Isolated from Saraca Asoca Enodophytic Fuungus, Lasiodiplodia Theobromae
(2018-05-16)Although the molecular mechanisms underlying the onset and progression of cancer has been unraveled to a great extend, cancer continues to remain a leading cause of death around the world. Clinical efficacy of the existing ... -
Role of Mycobacterium Tuberculosis RecG Helicase in DNA Repair, Recombination and in Remodelling of Stalled Replication Forks
(2018-05-14)Tuberculosis, caused by the infection with Mycobacterium tuberculosis remained as a major global health challenge with one third of world population being infected by this pathogen. M. tuberculosis can persist for decades ... -
Structural and Biochemical Analysis of DNA Processing Protein A (DprA) from Helicobacter Pylori
(2018-05-09)H. pylori has a panmictic population structure due to high genetic diversity. The homoplasy index for H. pylori is 0.85 (where 0 represents a completely clonal organism and 1.0 indicates a freely recombining organism) which ... -
Understanding the Dynamic Organization of the Presequence-Translocase in Translocation of Preproteins Across Mitochondrial Inner Membrane
(2018-05-08)Mitochondrion is an endosymbiotic organelle synthesizing ~1% of its proteome, while remaining ~99% of the proteins are encoded by the nuclear genome and translated on the cytosolic ribosome. Therefore active mitochondrial ... -
Infection of Human Cell Lines by Japanese Encephalitis Virus : Increased Expression and Release of HLA-E, a Non-classical HLA Molecule
(2018-04-24)Japanese encephalitis virus (JEV) causes viral encephalitis in new born and young adults that is prevalent in different parts of India and other parts of South East Asia with an estimated 6000 deaths per year. JEV is a ... -
Unraveling the Intricate Architecture of Human Mitochondrial Presequence Translocase - Insights on its Evolution and Role in Tumourigenesis
(2018-04-23)The present thesis focuses on the elucidation of human mitochondrial inner membrane presequence-translocation machinery with implications on cancer cell proliferation. Mitochondria are the endosymbiotic organelles in an ... -
Studies on Novel Functional Responses of Mouse Peritoneal Macrophages to Interferon-gamma : Roles of Nitric Oxide Synthase 2
(2018-04-18)Interferons are known cytokines that display antiviral, anti-proliferative and immuno-modulatory functions in the host. Interferon-gamma (Ifnγ) is the only type II family interferon that binds to the heterodimeric receptor ... -
Implications of Soluble Diacylglycerol Acyltransferases in Triacylglycerol Biosynthesis in Yeast and Plants
(2018-04-12)Lipids are stored in a cell for providing energy. The main advantages of storing lipids over carbohydrates like glycogen is that, lipids yield more energy after oxidation because they represent the highly reduced form of ... -
DNA Double-Strand Break Repair : Molecular Characterization of Classical and Alternative Nonhomologous End Joining in Mitochondrial and Cell-free Extracts
(2018-04-05)Maintenance of genomic integrity and stability is of prime importance for the survival of an organism. Upon exposure to different damaging agents, DNA acquires various lesions such as base modifications, single-strand ... -
Role of Grp 75 Chaperone Folding Machinery in the Maintenance of Mitochondrial Protien Quality Control
(2018-04-03)My research focuses on understanding the importance of human mitochondrial Hsp70 (Grp75) chaperone machinery for the maintenance of protein quality control inside the mitochondrial matrix. The investigations carried out ... -
Identification of the Minimal Domain of RNA Trihosphastase Activity in the L Protien of Rinderpest Virus and Charecterization of its Enzymatic Activities
(2018-04-03)Morbilliviruses belong to the family Paramyxoviridae of the Mononegavirale order of viruses. The Mononegavirale order contains viruses which contain negatively-polar, non-segmented and single stranded RNA genomes. This ... -
Functional Characterization of C4 Protien of Cotton Leaf Curl Kokhran Virus - Dabawali
(2018-03-07)1) Geminiviruses are a group of plant viruses which contain circular single stranded DNA molecules as their genomes and the capsid consists of two icosahedra fused together to form twinned or geminate particles. The largest ... -
Structure-Function Relationships of Saccharomyces Cerevisiae Meiosis Specific Hop 1 Protein : Implications for Chromosome Condensation, Pairing and Spore Formation
(2018-03-07)Meiosis is a specialized type of cell division essential for the production of four normal haploid gametes. In early prophase I of meiosis, the intimate synapsis between homologous chromosomes, and the formation of chiasmata, ... -
Mxr1p is a Global Regulator of Multiple Metabolic Pathways in the Methylotrophic Yeast Pichia Pastoris
(2018-03-01)The present study is aimed at examining the ability of Pichia pastoris to utilize acetate and amino acids as the sole sources of carbon. We demonstrate that the zinc finger transcription factor Mxr1p, which is a positive ... -
Understanding the Heat Shock Response Pathway in Plasmodium Falciparum and Identification of a Novel Exported Heat Shock Protein
(2018-02-27)Infections or diseases are not just stressful for the one who encounters it. The pathogens causing the same also have to deal with the hostile environment present in the host. The maintenance of physiological homeostatic ... -
Uncovering the Role of Mitochondrial Co-chaperones and Artificial Antioxidants in Cellular Redox Homeostasis
(2018-02-14)The role of mitochondria is multidimensional and ranges in vast areas, including apoptosis, cellular response towards stress, metabolism, which is regulated by a plethora of proteins, acting together to maintain cellular ... -
Cytosolic Lysophosphatidic Acid Acyltransferase : Implications in Lipid Biosynthesis in Yeast, Plants and Human
(2018-02-11)Cytosolic LPA acyltransferase in yeast An isooctane tolerant strain of S. cerevisiae KK-12 was reported to have increased saturated fatty acid content (Miura et. al., 2000). Amongst the various genes upregulated on isooctane ... -
Understanding in vivo Significance of Allosteric Regulation in mtHsp70s : Revealing its Implications in Parkinson's Disease Progression
(2018-01-28)Mitochondria are essential eukaryotic organelles, acting as the sites for numerous crucial metabolic and signalling pathways. The biogenesis of mitochondria requires efficient targeting of several hundreds of proteins from ...