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    Understanding the Sequence Dependence of NHEJ Mediated Double-strand Break Repair, and Identification of Novel DNA Ligase Inhibitors and their Potential Use as Cancer Therapeutics 

    Pandey, Monica
    Repair of DNA breaks is essential for maintenance of genomic integrity. DNA double-strand breaks (DSBs) are considered as the most harmful DNA lesions within the cells which if left unrepaired or are misrepaired, can lead ...

    Anti-thrombotic Secondary Metabolites from Endophytic Fungi of Datura Metel and Cassia Fistula 

    Anantha Krishna, T H
    Blood coagulation is a process that occurs normally in an animal during bleeding, to prevent the loss of blood from the body and is assisted by two key players -blood platelets and coagulation factors particularly thrombin. ...

    Exploring the Roles of Phase Variable HpyAII Restriction-modification System in the Human Pathogen Helicobacter pylori 

    Kumar, Sumith
    Helicobacter pylori is a Gram-negative microaerophilic bacteria known to infect as much as 80% of some populations with an average morbidity range of around 50% of the world population. It has been recognized as a definitive ...

    Understanding the Biology of Heat Shock Protein 90 in Opportunistic Fungal Pathogens 

    Chatterjee, Sharanya
    Heat shock protein 90 is one of the most abundant and evolutionary conserved class of molecular chaperones present throughout the biological kingdom. It is a specialist chaperone as its function extends beyond protein ...

    Computational and Experimental Approaches to Protein Design 

    Nagarajan, Deepesh
    Protein design is a rapidly maturing field, with the goal of designing proteins with customized structures and functions. A large number of protein structures are experimentally determined, which have facilitated an ...

    Isolation, Structure Elucidation and Functional Characterization of a Novel Cytotoxic Secondary Metabolite Phomafuranone, 2-Hydroxy-2, 4-dimethyl-5-[-1-propen-1-yl]-3(2H)-furanone, from Phoma tropica an Endophytic Fungus Isolated from Mappia foetida. 

    Kashyap, Srishti
    Cancer has become the leading disease-related cause of death in the human population. For example, in the United States, cancer is the second leading cause of death behind cardiovascular disease, and it is projected that ...

    Structural and Functional Characterization of Quadruplex DNA Structures in Human Acetyl-CoA Carboxylase 1 Gene Promoters and Stabilization of G-quadruplex DNA by Carbazole-benzimidazole Conjugates 

    Kaulage, Mangesh Hanumant
    A number of studies have established that DNA targeting is a successful strategy in anticancer therapy. In recent years, however, the focus has shifted from double-stranded DNA to alternative DNA motifs such as G-quadruplex ...

    Mapping the Functional Domain of Glycodelin A : An Immunomodulatory Lipocalin 

    Ponnalagu, Devasena
    Glycodelins (Gds) are dimeric, glycosylated proteins belonging to the lipocalin superfamily which are primarily transporters of small hydrophobic molecules. Gd is classified under the lipocalin superfamily as it shows 55 ...

    Oleosin, a Bifunctional Enzyme is Phosphoregulated by a Protein Kinase 

    Parthibane, V
    In eukaryotic cells, lipids are indispensable principal components that vitiate biological life. Lipids are classified into two major groups, polar and non-polar lipids. Polar lipids are phospholipids, whereas non-polar ...

    Understanding the Role of Lsm Domain in Translation Repression Activity of RGG-motif Containing Protein Scd6 

    Gole, Shirish Gajanan
    Control of gene expression in eukaryotes is regulated at various steps such as transcription, translation and protein degradation. Translation repression of mRNA regulates protein levels and maintains cell homeostasis. ...
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    AuthorAlok, Anshula (1)Anand, Praveen (1)Anantha Krishna, T H (1)Anujith Kumar, K V (1)Arun Nagaraj, V (1)Arvind, A (1)Bakshi, Rahul P (1)Bankapalli, Kondalarao (1)Banumathy, G (1)Beena, T K (1)... View MoreSubject
    Biochemistry (100)
    DNA Repair (7)Malaria (7)Heat Shock Protein 90 (6)Heat Shock Proteins (6)Hsp90 (5)P. falciparum (5)DNA Replication (4)Malarial Parasite (4)Molecular Chaperones (4)... View MoreDate Issued2010 - 2018 (68)2004 - 2009 (14)Has File(s)
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    etd@IISc is a joint service of SERC & J R D Tata Memorial (JRDTML) Library || Powered by DSpace software || DuraSpace
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