The present thesis focuses on the elucidation of human mitochondrial inner membrane presequence-translocation machinery with implications on cancer cell proliferation. Mitochondria are the endosymbiotic organelles in an ...

Mitochondrion is an endosymbiotic organelle synthesizing ~1% of its proteome, while remaining ~99% of the proteins are encoded by the nuclear genome and translated on the cytosolic ribosome. Therefore active mitochondrial ...

Stop codon readthrough is the process in which translation continues beyond a stop codon till a downstream, in-frame stop codon generating a polypeptide with a C-terminal extension. MTCH2 was selected as a potential ...