Messenger RNA translation is one of the most energy expensive steps in the process of gene expression and therefore translation regulation is critical for maintaining cellular homeostasis. In contrast to transcriptional ...

Mitochondria are semiautonomous organelles in a cell as they have their own genome that replicates independently. It plays a major role in oxidative phosphorylation due to which mitochondrial DNA (mtDNA) is frequently ...

Recent studies have demonstrated the role of E. coli UvrD as a replicative helicase that facilitates replication of rolling circle plasmids. Along with dinG and rep helicase, UvrD a so-called “accessory helicase” removes ...

Helicobacter pylori, a human pathogen dominating gastric microbial population, displays differential gene expression during various stages of stomach colonization. Topoisomerases play a crucial role in maintaining DNA ...

Our work demonstrates for the first time that PpRtgXp, a basic, helix-loop-helix (bHLH) protein, is a global regulator of carbon metabolism. PpRtgXp constitutively localizes inside the nucleus. Despite lacking the C-terminal ...

G-quadruplex (G4) secondary structures have been implicated in various biological processes, including gene expression, DNA replication and telomere maintenance. However, unresolved G4 structures impede replication ...

Unresolved G-quadruplex (G4) DNA secondary structures impede DNA replication and can lead to DNA breaks and to genome instability. Helicases are known to unwind G4 structures and thereby facilitate genome duplication. ...

Protein synthesis terminates at the first stop codon encountered by the ribosome. In stop codon readthrough, translation termination is suppressed, enabling the ribosomes to continue translation beyond the canonical stop ...