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Understanding the Regulation of mRNA Translation Repression by RGG-motif Proteins
Messenger RNA translation is one of the most energy expensive steps in the process of gene expression and therefore translation regulation is critical for maintaining cellular homeostasis. In contrast to transcriptional ...
Understanding the Mechanism of Double-strand Break Repair and Genome Fragility in Mammalian Mitochondria
Mitochondria are semiautonomous organelles in a cell as they have their own
genome that replicates independently. It plays a major role in oxidative phosphorylation due
to which mitochondrial DNA (mtDNA) is frequently ...
Role of Mycobacterium tuberculosis DinG and UvrD helicases in unwinding G-quadruplex DNA
Recent studies have demonstrated the role of E. coli UvrD as a replicative helicase that facilitates replication of rolling circle plasmids. Along with dinG and rep helicase, UvrD a so-called “accessory helicase” removes ...
Untangling the Helicobacter pylori genome: Deciphering the significance of zinc finger motif(s) in Topoisomerase I catalysis
Helicobacter pylori, a human pathogen dominating gastric microbial population, displays differential gene expression during various stages of stomach colonization. Topoisomerases play a crucial role in maintaining DNA ...
Role of Escherichia coli UvrD helicase in resolving G-quadruplex DNA structures
G-quadruplex (G4) secondary structures have been implicated in various biological processes,
including gene expression, DNA replication and telomere maintenance. However,
unresolved G4 structures impede replication ...
Metabolic and Pharmacological Modulations During IFN-γ signaling
Interferons, initially discovered for their antiviral properties, play pivotal roles in various biological processes, including host defense against pathogens, tumor surveillance, and disease pathogenesis. Interferon-gamma ...
Algorithms for Investigating, Decoding and Designing ligand recognition sites in proteins - A Structural Bioinformatics Approach to Studying Protein Function
All physical processes in living organisms are driven by specific biomolecular interactions.
Elucidating the characteristics of biomolecular interactions between proteins and their respective
small molecule ligands can ...
Role of Mycobacterium tuberculosis UvrD1 and UvrD2 helicases in resolving G-quadruplex DNA structures
Unresolved G-quadruplex (G4) DNA secondary structures impede DNA replication and can lead to DNA breaks and to genome instability. Helicases are known to unwind G4 structures and thereby facilitate genome duplication. ...
Comparative evaluation of retrograde regulatory proteins (Rtg1p, Rtg2p, and Rtg3p) of Saccharomyces cerevisiae and Pichia pastoris and identification of P. pastoris RtgXp as a novel regulator of multiple metabolic pathways
Our work demonstrates for the first time that PpRtgXp, a basic, helix-loop-helix (bHLH) protein, is a global regulator of carbon metabolism. PpRtgXp constitutively localizes inside the nucleus. Despite lacking the C-terminal ...
Stop codon readthrough of NNAT mRNA and its role in neuronal differentiation
Protein synthesis terminates at the first stop codon encountered by the ribosome. In stop codon readthrough, translation termination is suppressed, enabling the ribosomes to continue translation beyond the canonical stop ...