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    Understanding the Mechanism of Double-strand Break Repair and Genome Fragility in Mammalian Mitochondria 

    Dahal, Sumedha
    Mitochondria are semiautonomous organelles in a cell as they have their own genome that replicates independently. It plays a major role in oxidative phosphorylation due to which mitochondrial DNA (mtDNA) is frequently ...

    Unraveling the Intricate Architecture of Human Mitochondrial Presequence Translocase - Insights on its Evolution and Role in Tumourigenesis 

    Sinha, Devanjan (2018-04-23)
    The present thesis focuses on the elucidation of human mitochondrial inner membrane presequence-translocation machinery with implications on cancer cell proliferation. Mitochondria are the endosymbiotic organelles in an ...

    The dual-targeting of Saccharomyces cerevisiae Pso2 into the nucleus and mitochondria is regulated by post-translational modifications: Implications for organelle-specific DNA repair 

    Somashekara, S C
    The repair of DNA interstrand crosslinks (ICLs) involves the concerted action of multiple DNA repair pathways. In eukaryotes, ICLs are sensed and repaired by replication-coupled or replication-independent mechanisms in ...

    Stop codon readthrough in MTCH2 mRNA and its role in mitochondrial physiology 

    Lekha, E M
    Stop codon readthrough is the process in which translation continues beyond a stop codon till a downstream, in-frame stop codon generating a polypeptide with a C-terminal extension. MTCH2 was selected as a potential ...

    Uncovering the role of NFS1 in Fe-S cluster biogenesis and in the development of Infantile mitochondrial complex II/III deficiency (IMC23D) disease progression and 2. Screening single domain antibody (VHH) against a membrane transporter 

    Namala, Gayatri Devi M
    The mitochondrion is a double membrane-bound organelle found in all eukaryotic organisms. Mitochondria are endosymbiotic, autogenous organelles referred to as “Powerhouse” of cells due to their ability to synthesize ATP ...

    Understanding the architecture of mitochondrial presequence translocase machinery and its implications in ALS progression 

    Waingankar, Tejashree Pradip
    The current thesis describes the structural organization of the presequence translocase machinery and its functional association with ALS pathogenesis. The TIM23 complex is essential for the mitochondrial biogenesis of ...

    Understanding the role of DNAJC30 and ISCU in mitochondrial homeostasis 

    Birje, Abhijit
    Williams-Beuren Syndrome (WBS) is a rare multisystem genomic disorder characterized by mild to moderate cognitive impairment, unique personality traits, distinctive facial features, cardiovascular problems, and infantile ...

    Understanding the role of mtHsp70 in regulating mitochondrial homeostasis: revealing its significance in Congenital Sideroblastic Anemia progression 

    Vishwanathan, Vinaya
    Mitochondria are ubiquitous organelles placed at the nexus of several metabolic and signaling pathways essential for cell survival. Therefore, maintaining a healthy and functional organelle becomes paramount for the cell. ...

    Investigating DJ-1 homologs in maintaining genome integrity through glycation repair of macromolecules: Implications in regulating mitochondrial health 

    Susarla, Gautam Ratna Kiran
    The current thesis work focuses on DJ-1 superfamily proteins and their role in protection against toxic glycating carbonyls such as Methylglyoxal (MG) and Glyoxal (GO). Our study reveals that yeast DJ-1 homologs (Hsp31 ...

    Understanding the Dynamic Organization of the Presequence-Translocase in Translocation of Preproteins Across Mitochondrial Inner Membrane 

    Pareek, Gautam (2018-05-08)
    Mitochondrion is an endosymbiotic organelle synthesizing ~1% of its proteome, while remaining ~99% of the proteins are encoded by the nuclear genome and translated on the cytosolic ribosome. Therefore active mitochondrial ...

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    AuthorBirje, Abhijit (1)Dahal, Sumedha (1)Lekha, E M (1)Namala, Gayatri Devi M (1)Pareek, Gautam (1)Sinha, Devanjan (1)Somashekara, S C (1)Susarla, Gautam Ratna Kiran (1)Vishwanathan, Vinaya (1)Waingankar, Tejashree Pradip (1)Subject
    Mitochondria (10)
    NATURAL SCIENCES (6)Biochemistry (3)ALS pathogenesis (1)Apoptosis - Mitochondria (1)Cancer - Mitochondria (1)Chaperone (1)chromosomes (1)Congenital Sideroblastic Anemia (1)DJ-1 proteins (1)... View MoreDate Issued2018 (2)Has File(s)Yes (10)

    etd@IISc is a joint service of SERC & J R D Tata Memorial (JRDTML) Library || Powered by DSpace software || DuraSpace
    Contact Us | Send Feedback | Thesis Templates
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