Protein synthesis terminates at the first stop codon encountered by the ribosome. In stop codon readthrough, translation termination is suppressed, enabling the ribosomes to continue translation beyond the canonical stop ...

Interferons, initially discovered for their antiviral properties, play pivotal roles in various biological processes, including host defense against pathogens, tumor surveillance, and disease pathogenesis. Interferon-gamma ...

Unresolved G-quadruplex (G4) DNA secondary structures impede DNA replication and can lead to DNA breaks and to genome instability. Helicases are known to unwind G4 structures and thereby facilitate genome duplication. ...

G-quadruplex (G4) secondary structures have been implicated in various biological processes, including gene expression, DNA replication and telomere maintenance. However, unresolved G4 structures impede replication ...

Type 2 Diabetes (T2D) is a complex and heterogeneous disease characterized by hyperglycemia, insulin resistance, and impaired insulin secretion. While often interrelated, hyperglycemia and insulin resistance represent ...