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Nuclear Behaviour In Heterokaryons : Genetic And Molecular Analysis Of (his-3+ his-3+) Heterokaryons Of Neurospora Crassa
(Indian Institute of Science, 2005-12-06)
In contrast to plant and animal cells, the fungal cells are multinucleate. A consequence of their multinucleate condition is heterokaryosis — the occurrence of genetically different nuclei in a common cytoplasm. In nature ...
Role of Mammalian RAD51 Paralogs in Genome Maintenance and Tumor Suppression
(2018-01-28)
My research was focused on understanding the importance of mammalian RAD51 paralogs in genome maintenance and suppression of tumorigenesis. The investigation carried out during this study has been addressed toward gaining ...
The Role of Saccharomyces Cerevisiae MRX Complex and Sae2 in Maintenance of Genome Stability
(2018-06-11)
In eukaryotes, the repair of DSBs is accomplished through two broadly defined processes: Non-Homologous End Joining (NHEJ) and Homologous Recombination (HR). The central step of HR is pairing and exchange of strands between ...
Fatty Acid And Triacylglycerol Synthesis In Developing Seeds Of Groundnut (Arachis Hypogaea) And Pisa (Actinodaphne Hookeri)
(Indian Institute of Science, 2005-04-18)
The term "lipid" covers an extremely diverse range of chemical or molecular species. Lipids, defined as molecules that are sparingly soluble in water but readily soluble in organic solvents, are broadly categorized into ...
Biodegradation Of 1-Naphthoic Acid
(Indian Institute of Science, 2005-04-06)
Polycyclic aromatic hydrocarbons (PAHs) are compounds containing carbon and hydrogen atoms of fused benzene rings in linear, angular or cluster arrangements. These compounds have a large (negative) resonance energy, resulting ...
New Anticancer Secondary Metabolites from an Endophytic Fungus Chaetomium Nigricolor Isolated from Catharanthus Roseus : Structural Elucidation and Molecular Mechanism Underlying Anticancer Effects
(2018-06-13)
Cancer has become a major health problem due to its high rate of morbidity and mortality. Severe side effects associated with most of the available anticancer drugs and the development of the drug resistant cells are the ...
Molecular Insights into Lymphoid Malignancy : Role of Transcription Factor BCL11B in T-cell Leukemia Genesis and Biochemical Characterization of DNA Binding Domain of RAG1
(2018-06-29)
The lymphoid tissues consist of distinct cell subpopulations of B and T cell lineages and possess complex signaling pathways that are controlled by a myriad of molecular interactions. During the fine-tuned developmental ...
Arabidopsis Serine/Threonine/Tyrosine Protein Kinase : Implications in Growth And DEvelopment
(2018-07-19)
Protein phosphorylation is a key cellular regulatory mechanism. Phosphorylation can either activate or inhibit the function of a particular protein. Activation of protein kinases has been implicated in response to light, ...
Characterisation Of DNA Llgase And Pairing Activities From A Partially Purified Fraction From Rat Testis
(Indian Institute of Science, 2005-04-06)
Homologous genetic recombination is a central feature of meiosis in most sexually dividing organism. It leads to the establishment of new linkage relationships between genes and is crucial for the successful completion of ...
Immunomodulatory Activity of Glycodelin : Implications in Allograft Rejection
(2018-06-15)
Glycodelin, a homodimeric glycoprotein belonging to the lipocalin superfamily, is synthesised predominantly by the cells of the reproductive system of certain primates including humans. Of the four different known glycoforms ...