Browsing Biochemistry (BC) by Subject "stop codon readthrough"

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Hominini-specific regulation of cell cycle by stop codon readthrough of FEM1B

Akhtar, Md Noor

In certain mRNAs ribosomes continue translation beyond the canonical stop codon to generate longer isoform with a C-terminal extension. This phenomenon is termed stop codon readthrough (SCR). Previously, a genome-wide ...
Physiological Significance of Stop Codon Readthrough

Som, Saubhik

Regulation of translation, the process by which ribosomes synthesize proteins from mRNAs, is critical to maintain cellular proteostasis. Dysregulation of translation is implicated in several neurodegenerative, metabolic, ...
Translation in the 3'Untranslated Region of Mammalian Transcripts

Kar, Debaleena

Mammalian mRNAs generally have a 5'UTR (untranslated region), a coding DNA sequence, and a 3'UTR. The 3'UTR of mRNA is generally believed to be the untranslated region of the mRNA. However, there are certain instances ...