Browsing Biochemistry (BC) by Subject "DNA Damage"
Now showing items 1-6 of 6
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Insights Into Transcription-Repair Coupling Factor From Mycobacterium Tuberculosis
(2014-12-01)Introduction Nucleotide excision repair (NER) is a highly conserved pathway involved in repair of a wide variety of structurally unrelated DNA lesions. One of the well characterized NER systems is from E. coli which ... -
Mechanistic Insights into Radioprotection by Caffeine and Understanding Impact of Caffeine on Nonhomologous End Joining: Implications in Cancer
Maintenance of genome integrity is of utmost importance for the survival of any organism. Genetic instability is usually associated with various disorders, and it often leads to premature aging and predisposition to various ... -
Physiological And Exogenous Means of Regulating DNA Damage Response : Insights into Mechanisms of DNA Repair And Genomic Instability
(2017-09-23)Maintenance of genomic integrity with high fidelity is of prime importance to any organism. An insult which may result in compromised genome integrity is prevented or its consequences are monitored by advanced cellular ... -
Role of Mycobacterium Tuberculosis RecG Helicase in DNA Repair, Recombination and in Remodelling of Stalled Replication Forks
(2018-05-14)Tuberculosis, caused by the infection with Mycobacterium tuberculosis remained as a major global health challenge with one third of world population being infected by this pathogen. M. tuberculosis can persist for decades ... -
The Role of Saccharomyces Cerevisiae MRX Complex and Sae2 in Maintenance of Genome Stability
(2018-06-11)In eukaryotes, the repair of DSBs is accomplished through two broadly defined processes: Non-Homologous End Joining (NHEJ) and Homologous Recombination (HR). The central step of HR is pairing and exchange of strands between ... -
Understanding the Mechanism of DNA Double-Strand Break (DSB) Repair in Mitochondria and Various Mammalian Organs.
Various exogenous and endogenous agents can damage DNA. Exogenous agents include chemicals and radiation, such as ionizing radiations and UV rays, while endogenous agents include DNA replication errors, reactive oxygen ...