Browsing Biochemistry (BC) by thesis submitted date"2019"
Now showing items 1-8 of 8
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Biochemical characterization of UvrD helicase and its 1 interplay with DNA mismatch repair proteins in 2 Neisseria gonorrhoeae
UvrD helicase belongs to type I superfamily of helicases. It participates in Nucleotide Excision Repair (NER) and DNA Mismatch Repair (MMR). It also participates in the rolling circle replication. It has been shown that ... -
Comparative evaluation of retrograde regulatory proteins (Rtg1p, Rtg2p, and Rtg3p) of Saccharomyces cerevisiae and Pichia pastoris and identification of P. pastoris RtgXp as a novel regulator of multiple metabolic pathways
Our work demonstrates for the first time that PpRtgXp, a basic, helix-loop-helix (bHLH) protein, is a global regulator of carbon metabolism. PpRtgXp constitutively localizes inside the nucleus. Despite lacking the C-terminal ... -
Determination of significance of SUMOylation of the Smc5/6 complex
The fascination of scientists to the Smc5/6 complex began in the 1990s, with the characterization of UV and γ radiation-sensitive rad18 mutant and its identification as a component of a novel Structural Maintenance of ... -
Investigating DNA structural basis for fragility during chromosomal translocations associated with human B-cell lymphomas
Genome integrity is essential for normal cellular functions. Erroneous repair of DNA double-strand breaks (DSBs) could lead to chromosomal rearrangements, including chromosomal translocations that may result in altered ... -
Kinetic, Catalytic and Epigenetic Properties of HpyAXVII DNA Methyltransferase – a Phasevarion in the Human Pathogen Helicobacter pylori
Helicobacter pylori is the leading cause of gastric cancer in human beings. It is a helix-shaped, Gram-negative, motile bacteria that colonizes the gastric mucosa and eventually the gastric epithelium. It has an overabundance ... -
Metabolic Regulation of Gametocytogenesis in Malaria
Plasmodium sp. is an obligate intracellular protozoan parasite causing malaria and is responsible for more than 500,000 human deaths annually. P. falciparum and P. vivax are the two major species causing malaria in humans. ... -
Role of mammalian RAD51 paralogs in replication stress response and genome maintenance
The focus of my research has been to understand the molecular mechanisms underlying the role of mammalian RAD51 paralogs in genome maintenance and tumor suppression. The investigation carried out during this study has ... -
Understanding the Mechanism of Double-strand Break Repair and Genome Fragility in Mammalian Mitochondria
Mitochondria are semiautonomous organelles in a cell as they have their own genome that replicates independently. It plays a major role in oxidative phosphorylation due to which mitochondrial DNA (mtDNA) is frequently ...