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Targeting RNA with Drug-Like Small Molecules and Fluorescent Probes for Mapping Cell Fate
Part A
Ribonucleic acid (RNA) plays a central role in various essential functions such as cellular information transfer and gene regulations in living organisms.1 Recent studies have shown that RNA is involved in various ...
Computational Studies of the Electronic Structures and Ring Contraction Reactions of Pn (n=4-6) Ring in Double and Triple Decker Complexes, and an Orbital Engineering Approach to Stabilise Borozene (B6H6)
The well established chemistry of ferrocene1-3 and different sandwich scaffolds4,5 with organic rings prompted us to explore the electronic structures and reactivity of sandwich complexes involving inorganic rings, i.e., ...
Synthesis and X-ray Crystallographic Studies of Salts, Co-crystals, Solvates of some Amine containing Active Pharmaceutical Ingredients and In-situ Cryo Crystallographic Studies on some Organic Liquids
Chapter I describes the general introductory note to describe the common terms like crystalline solids, properties, and their uses pharmaceutical industry. The definition of common terms like Salts, Co-crystal, solvates ...
Photodynamic Therapy and Cellular Imaging using Platinum(II) Conjugates of Boron-dipyrromethene and Curcumin
The present thesis portrays the rational design and successful synthesis of platinum(II) complexes for achieving photoactivated dual action anticancer properties. The research project centers on synthesis, comprehensive ...
Exploring Hyperbranched Polymers as Multifunctional Scaffolds
Hyperbranched polymers (HBPs) are highly branched macromolecules that exhibit excellent solubility, low melt viscosity, and they possess a multitude of modifiable peripheral functional groups.1 Unlike their structurally ...
Mechanistic Investigation and Engineering of a Membrane-Bound Hydrocarbon-Producing Metalloenzyme
The pursuit of sustainable and environmentally friendly fuels, such as biofuels, is gaining attention as an alternative to diminishing fossil fuel resources. Consequently, there is a significant focus on the sustainable ...
Ultrafast Processes in Energetic Molecules
The thesis has been presented in two parts. In first part of the thesis, ultrafast relaxation dynamics of UV excitation induced chemistry via electronically excited states has been discussed. Taking one example from each ...
Computational Studies of Heavier Main Group Elements: Control of Lewis Acidity of Bi and Sb by Charge and Ligand Design, and Structural Variations of [Fe(CO)4]2E2 and E2CH2 Isomers (E = C–Pb)
Traditional main group compounds demonstrate Lewis acidity due to the presence of vacant p- orbitals. Hydrides of lighter main group elements, such as NH3, function as Lewis bases. However, introducing highly electronegative ...
Substituted Alkylammonium Layered Lead Halide Perovskites: An Experimental and Computational Study
Organic-inorganic hybrid metal halide perovskites have emerged as a new class of semiconducting materials with potential applications in solar devices, catalyzed by the remarkable power conversion efficiency of over 21% ...
B, N containing π- conjugated systems: room temperature phosphorescence, fullerene complexation, and cell differentiation
Advances in heteroatom (B, N, and B-N) incorporated π-conjugated systems have attracted considerable attention because of their desirable properties and widespread applications. Substitution of isoelectronic B–N units for ...