Division of Biological Sciences: Recent submissions
Now showing items 641-660 of 1177
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Design and Application of Temperature Sensitive Mutants in Essential Factors of RNA Splicing and RNA Interference Pathway in Schizosaccharomyces Pombe
(2018-05-10)Gene deletions are a powerful method to uncover the cellular functions of a given gene in living systems. A limitation to this methodology is that it is not applicable to essential genes. Even for non-essential genes, gene ... -
Regulation of the Principal Cell Division Protein FtsZ of Escherichia Coli by Antisense RNA and FtsH Protease
(2018-05-10)The PhD thesis is on the studsy of the influence of the ftsZ antisense RNA and FtsH protease on the synthesis and function of the Escherichia coli cytokinetic protein, FtsZ, which mediates septation during cell division. ... -
Immune Evasion and Survival Strategies of Mycobacterium : Role for Host Signaling Pathway-Mediated Micro RNAs and Epigenetic Regulation
(2018-05-09)The genus Mycobacterium represents more than 120 species of bacteria including the pathogenic M. tuberculosis, the etiological agent of tuberculosis. The host mounts a robust inflammatory and cell-mediated response to ... -
The Role of Nursery Size and Plant Phenology on the Reproduction of and Relationships within a Fig-fig Wasp Nursery Pollination System
(2018-05-09)Obligate nursery pollination mutualisms such as the fig–fig wasp system, with their central plant–pollinator mutualism associated with non-pollinating satellite wasp species, can function as closed system microcosms ... -
Structural Studies on the Role of Hinge involved in Domain Swapping in Salmonella Typhimurium Stationary Phase Survival Protein (SurE) and Sesbania Mosaic Virus Coat Protein
(2018-05-09)A unique mechanism of protein oligomerization is domain swapping. It is a feature found in some proteins wherein a dimer or a higher oligomer is formed by the exchange of identical structural segments between protomers. ... -
Structural and Biochemical Analysis of DNA Processing Protein A (DprA) from Helicobacter Pylori
(2018-05-09)H. pylori has a panmictic population structure due to high genetic diversity. The homoplasy index for H. pylori is 0.85 (where 0 represents a completely clonal organism and 1.0 indicates a freely recombining organism) which ... -
Targeting Gonadotropins to the Dendritic Cells : A Novel Strategy for Animal Immunocontraceptive Vaccine
(2018-05-09)Contraception through a vaccine has been a very attractive proposition and several attempts were made in the past. To achieve contraception through immunological means, several points need to be considered. First, the ... -
Structural Studies on Heat Shock Protein 90 from Dictyostelium Discoideum and Oryza Sativa
(2018-05-09)Molecular chaperones are proteins that interact with and aid in stabilization and activation of other proteins. Chaperones help proteins attain their three dimensional conformation, without forming a part of the final ... -
Structural and Related Studies on Mycobacterial Lectins
(2018-05-09)This thesis is concerned with the first ever X-ray crystallographic and complimentary solution studies on mycobacterial lectins. Lectins, described as multivalent carbohydrate binding proteins of non-immune origin, are ... -
Characterization of Host Protein Interactions with HCV RNA : Implications in Viral Translation, Replication and Design of Antivirals
(2018-05-09)HCV genome is a positive sense single-stranded RNA containing a single open reading frame (ORF) flanked by untranslated regions (UTRs), 5’UTR and 3’UTR.Initiation of HCV RNA translation is mediated by internal ribosome ... -
Protein Engineering and Stabilization of HIV-1 Envelope Glycoprotein
(2018-05-09)A number of viral diseases such as Hepatitis B, small pox, measles, rubella and polio have effective vaccines to control or eradicate them. HIV-1 is a lentivirus which infects human immune cells and leads to the disease ... -
Small Heat Shock Proteins from Oryza Sativa and Salmonella Enterica
(2018-05-09)Small heat shock proteins (sHSPs) are a ubiquitous family of molecular chaperones that play a vital role in maintaining protein homeostasis in cells. They are the first line of defence against the detrimental effects of ... -
Understanding the Dynamic Organization of the Presequence-Translocase in Translocation of Preproteins Across Mitochondrial Inner Membrane
(2018-05-08)Mitochondrion is an endosymbiotic organelle synthesizing ~1% of its proteome, while remaining ~99% of the proteins are encoded by the nuclear genome and translated on the cytosolic ribosome. Therefore active mitochondrial ... -
Spike-Timing-Dependent Plasticity at Excitatory Synapses on the Rat Subicular Pyramidal Neurons
(2018-05-08)The subiculum is a structure that forms a bridge between the hippocampus and the entorhinal cortex (EC) in the brain, and plays a major role in the memory consolidation process. It consists of different types of pyramidal ... -
Structural Studies on Bacterial Adenylosuccinate Lyase and Sesbania Mosaic Virus Protease
(2018-05-08)The three-dimensional structures of biological macromolecules and molecular assemblies are becoming increasingly important with the changing methodologies of drug discovery. The structures aid in understanding of protein ... -
Protein Engineering of HIV-1 Env and Human CD4
(2018-05-01)Since, its discovery over three decades ago, HIV has wrecked havoc worldwide. According to the UNAIDS report 2011, at present 34 million people is living with HIV and AIDS vaccine with broadly neutralizing activity still ... -
Unfolding the Mechanism of Notch1 Receptor Activation : Implications in Cancer Stem Cell Targeting
(2018-05-01)Notch receptors and ligands are single-pass transmembrane proteins which play important roles in cell-cell communication. Notch in ‘harmony’ with other signaling pathways regulate the entire diversity of metazoan life ... -
Infection of Human Cell Lines by Japanese Encephalitis Virus : Increased Expression and Release of HLA-E, a Non-classical HLA Molecule
(2018-04-24)Japanese encephalitis virus (JEV) causes viral encephalitis in new born and young adults that is prevalent in different parts of India and other parts of South East Asia with an estimated 6000 deaths per year. JEV is a ...