Division of Biological Sciences: Recent submissions
Now showing items 621-640 of 1177
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Molecular Determinants of Mutant Phenotypes in the CcdAB Toxin -Antitoxin System
(2018-05-29)A major challenge in biology is to understand and predict the effect of mutations on protein structure, stability and function. Chapter 1 provides a general introduction on protein sequence-structure relationships and use ... -
Understanding the Role of ZCF32, a Zinc Cluster Transcription Factor, in Candida albicans Biology
(2018-05-25)As a human fungal pathogen, Candida albicans can cause a wide variety of disease conditions ranging from superficial to systemic infections. Many of these infections are caused by an inherent ability of the pathogen to ... -
Ecology of Fungus-Farming by Termites : Fungal Population Genetics and Defensive Mechanism of Termites against the Parasitic Fungus Pseudoxylaria
(2018-05-25)All living organisms require food for growth and survival. Heterotrophs depend on autotrophs such as green plants which can synthesize their own food unlike heterotrophic animals. Among heterotrophs, only humans and some ... -
Structural Studies on SeMV Chimeras and TSV : Insights into Capsid Assembly
(2018-05-23)Assembly of virus capsid protein (CP) into icosahedrally symmetric particles is an intriguing and elegant process. In most cases of virus assembly, a large number of identical protein subunits self-assemble to generate a ... -
Probing the Role of Highly Conserved Residues in Triosephosphate Isomerase : Biochemical & Structural Investigations
(2018-05-23)Conserved residues in protein are crucial for maintaining structure and function, either by direct involvement in chemistry or indirectly, by being essential for folding, stability and oligomerisation and are mostly clustered ... -
Developmental and Functional Roles of Troponin-T Isoforms, and Exploring Genome-Wide Alterations in Drosophila Indirect Flight Muscle Mutants
(2018-05-23)Muscle contraction is a highly fine-tuned process that requires the precise and timely construction of large protein sub-assemblies to form sarcomeres, the individual contractile units. Mutations in many of the genes ... -
Finding the Way Back Home : A study of Spatial Orientation, Navigation and Homing Behaviour in the Social Wasp Ropalidia marginata
(2018-05-23)For most of the animals, if not all, finding their way to a particular place is crucial for survival. To address this challenge of way-finding, different animals have evolved with different homing strategies. Social ... -
Systemic Profiling of Two Component Signaling Networks in Mycobacterium Tuberculosis
(2018-05-23)Mycobacterium tuberculosis, the causative organism of the disease tuberculosis (TB) in humans, leads to nearly two million deaths each year. This versatile pathogen can exist in highly distinct physiological states such ... -
Effect of Ultrasound on Neuronal Network Communication
(2018-05-22)Low intensity and low frequency ultrasound has been shown to modulate ion channel currents, membrane capacitive currents, and as a result, neuronal activity. Ultrasound has been used as a non-invasive way to modulate ... -
Dynamics of Protein Kinases : Its Relationship to Functional Sites and States
(2018-05-22)A cell is a highly complex, ordered, and above all, a robust system. It copes with in-trennel and external uncertainties like heterogeneous stimuli, errors in processing and execution, and changes within and outside the ... -
Elucidation of the Role of Nse1, a RING Domain Containing Component of Smc5/6 complex, in Maintenance of Chromosome Stability in Saccharomyces cerevisiae
(2018-05-21)Structural Maintenance of Chromosomes (SMC) proteins are a highly conserved class of proteins required for the maintenance of genome stability and regulate nearly all aspects of chromosome biology. Eukaryotes, such as the ... -
Structural and Functional Studies on the Mycobacterium tuberculosis σ factor σJ
(2018-05-21)Regulation of transcription in prokaryotes is primarily governed at the transcription initiation step. This feature has been extensively characterized in model prokaryotes notably Escherichia coli and Bacillus subtilis. ... -
Biochemical, Biophysical and Evolutionary Perspectives of Zinc Finger Proteins in Mycobacterium smegmatis
(2018-05-21)Transcription is a major step in expression of genes of a given organism. Due to environmental constrains this step must be regulated in the favour of the sustenance and growth of the organism. Here comes the relevance of ... -
Adjunct Therapy with Curcumin for the Treatment of Malaria : Studies in a Murine Model
(2018-05-16)Malaria accounts for 198 million cases worldwide; with a high mortality rate. 584000 deaths were reported in 2013. Malaria is a re-emerging disease globally due to drug resistance, parasite recrudescence and non-availability ... -
Structure Elucidation and Biological Evaluation of a Novel Steroidal Saponin, Cholestanol Glucoside Isolated from Saraca Asoca Enodophytic Fuungus, Lasiodiplodia Theobromae
(2018-05-16)Although the molecular mechanisms underlying the onset and progression of cancer has been unraveled to a great extend, cancer continues to remain a leading cause of death around the world. Clinical efficacy of the existing ... -
Biochemical and Functional Studies on the Evolutionarily Conserved MPPED1/MPPED2 Protein Family
(2018-05-16)A large number of evolutionarily conserved genes have been identified by comparative genomics approaches. However, a considerable fraction of these genes lack functional characterization despite the availability of several ... -
Structural Feature of Prokaryotic Promoters and their Role in Gene Expression
(2018-05-14)Transcription initiation is an important step in the process of gene regulation in prokaryotes. Promoters are stretches of DNA sequence that are present in the upstream region of transcription start sites (TSSs), where RNA ... -
Role of Mycobacterium Tuberculosis RecG Helicase in DNA Repair, Recombination and in Remodelling of Stalled Replication Forks
(2018-05-14)Tuberculosis, caused by the infection with Mycobacterium tuberculosis remained as a major global health challenge with one third of world population being infected by this pathogen. M. tuberculosis can persist for decades ... -
Species Ranges, Richness and Replacement of Trees in the Evergreen Forests of the Western Ghats
(2018-05-14)It has been more than two centuries since the latitudinal pattern of increase in taxonomic richness from poles to equator was first documented. After two centuries of research, and with more than two dozen hypotheses ... -
Molecular Characterization of Bacillus Subtilis Oxidoreductases involved in the Bacilysin Synthesis
(2018-05-11)The biosynthetic pathway for the production of the dipeptide antibiotic bacilysin has been the subject of intense research over the past three decades. These studies revealed the role of multiple enzymes in the biosynthesis ...