Division of Biological Sciences: Recent submissions
Now showing items 181-200 of 1085
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Structural and Biophysical studies to evaluate the influence of oligomerization on biomolecular function
Oligomeric proteins are more common than monomers. This aspect of molecular evolution substantially contributes to functional diversity and the acquisition of features such as cooperativity and regulatory mechanisms. Not ... -
Studies on exosomal microRNAs and proteins associated with Hepatitis C and Dengue virus induced pathogenesis
Studies on the exosomal microRNAs and proteins associated with Hepatitis C and Dengue virus-induced pathogenesis. Hepatitis C virus and Dengue virus are the group of positive-strand RNA viruses belonging to the family ... -
Functional characterization of WD40-repeat protein, WDR8, in Zebrafish to gain insight into its role in Isolated Microspherophakia
WD40-repeat (WDR) proteins are a family of proteins that are characterized by widespread occurrence, low level of sequence conservation, common structural conformation (β propeller structure) and functional diversity. ... -
Structural and functional insights of biological macromolecules associated with infectious diseases – single particle cryo-electron microscopy based studies
In the global context, particularly in India, the two most important infectious diseases among many others are Tuberculosis (TB), an age-old disease and COVID-19, a new-age disease. This thesis focuses on some of the key ... -
Activin and TGF-β signaling: Differential role of a Serine/Threonine phosphate in the regulation of SMAD2 activity
Activins are the most prominent members of the Activin/Inhibin branch of the TGF-β superfamily. Similar to TGF-β, they play an essential role in regulating multiple physiological processes such as development, reproductive ... -
First thorough characterization of the structure, interactions and specificity of an archeal lectin with implication for TB infection
Decades long studies on plant lectins carried out in this laboratory have contributed substantially to glycobiology and helped in the initiation and development of macromolecular crystallography in India. Subsequently the ... -
Roles of Drosophila Beadex and CG9650 in the development and functioning of the larval neuromuscular junctions
In eukaryotes, all voluntary and involuntary actions like, cognition, learning & memory, voluntary movements, feeding, etc., are coordinated by the employment of neuronal circuitry that transmits the signal from the ... -
Manipulating Bacterial and Host Reactive Oxygen Species (ROS)- based mechanisms to potentiate killing of Mycobacterium tuberculosis (Mtb)
Mycobacterium tuberculosis (Mtb) is evolutionarily equipped to resist exogenous reactive oxygen species but shows vulnerability to an increase in endogenous ROS (eROS). Since eROS is an unavoidable consequence of aerobic ... -
Understanding the Mechanism of Noncanonical Functions of RAGs in Lymphoid Cancer and Glioblastoma
Recombination activating genes (RAGs) composed of RAG1 and RAG2, are the endonuclease involved in V(D)J recombination, which is critical for adaptive immunity in mammals. Activation-induced cytidine deaminase (AID), expressed ... -
Ground-dwelling arthropods across human land use: Interpreting the spatial and temporal dimensions of beta diversity
This study investigates beta diversity and its partitions to quantify the influence of different processes that drive spatial and temporal variation in ground-dwelling arthropod assemblages. First, ant assemblages across ... -
Probing Protein Sequence-Function Relationships using Deep Mutational Scanning
Deep Mutational Scanning (DMS) approaches help elucidate sequence-function-phenotype relationships in proteins, which ultimately improves our understanding of residue (or nucleotide)-specific contributions to protein ... -
Understanding the role of hydrogen sulfide in regulating redox homeostasis and inflammation during cellular senescence
Aging involves the time-dependent deterioration of physiological functions, which can be attributed to various factors. Cellular senescence has been shown to be akin to aging, which involves alteration in redox homeostasis ... -
Role of Hydrogen Sulfide Gas in Modulating HIV-1 Latency and Reactivation
Human Immunodeficiency Virus 1 (HIV-1) remains a global public health threat, claiming 690 thousand people’s lives in 2020 and causing 1.5 million new infections. The advent of combinatorial antiretroviral therapy (ART) ... -
Regulation of carbon metabolism in Pichia pastoris by Mxr1p and identification of novel regulators
Pichia pastoris (a.k.a. Komagataella phaffii), a widely used yeast for recombinant protein production, is cultured under a variety of conditions ranging from shake flasks to large bioreactors employing minimal, chemically ... -
Exploring Nature's Inventory: Investigating the Role of Amide to Thioamide Substitution on Protein Stability
The peptide backbone holds a protein together and plays a crucial role in guiding its three-dimentional structure. The tertiary structure of proteins regulates several biological processes. Therefore, peptide bond modification ... -
Identification, characterization, structure, and assembly of type III toxin-antitoxin systems from Escherichia coli
Bacteria adopt several defense strategies to enable their survival against the environmental threats they encounter from time to time. Toxin-antitoxin (TA) systems are being understood as a key bacterial defense mechanism ... -
Integrative modeling of NS3 helicase function with molecular kinetics, molecular simulations and machine learning
The viral NS3 helicase is a crucial enzyme involved in the RNA replication of positive strand ssRNA viruses of the Flaviviridae family. The NS3 is an active motor that binds RNA and couples ATP hydrolysis to the mechanical ... -
HIV-1 and SARS-CoV-2 immunogen design
Human Immunodeficiency Virus (HIV-1) is the aetiologic agent of AIDS. Presently there are ~38 million HIV-1 infected individuals worldwide and ~1 million deaths in 2019. Since its discovery, the quest for vaccine candidate ... -
Role of mammalian RAD51 paralogs in replication stress response and genome maintenance
The focus of my research has been to understand the molecular mechanisms underlying the role of mammalian RAD51 paralogs in genome maintenance and tumor suppression. The investigation carried out during this study has ... -
Mechanism of the Development of Genetic Resistance to Antibiotics Mediated by three Reactive Oxygen Species in Mycobacterium smegmatis
Bacteria use different means to survive in the continued presence of antibiotics. We find that upon prolonged exposure to antibiotics, mycobacteria put up a triphasic response comprised of a logarithmic reduction of the ...