Division of Biological Sciences: Recent submissions
Now showing items 1-20 of 1085
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Deciphering Hypoxic Adaptations in Cutibacterium acnes using Multi-omics Profiling and Systems Modelling
The opportunistic skin anaerobe Cutibacterium acnes (C. acnes) contributes to skin homeostasis with its antioxidant and immunomodulatory activities. C. acnes (formerly known as Propionibacterium acnes) is an aerotolerant, ... -
Deep Mutational Scanning Analyses of Protein Stability and Function
Protein stability is critical to understanding protein function, folding, and interactions within living organisms. It plays a key role in protein engineering, where designing stable proteins is essential for developing ... -
Protein folding and Disulphide rich peptide(s) folds
Protein folding and protein folds are two sides of a coin. The study of protein folding processes is crucial for advancing our knowledge in fundamental cellular processes while the study of protein folds is important for ... -
Structural and functional characterization of a bacterial TenpIN type III toxin-antitoxin system and its potential as an antibacterial strategy
Bacterial type III toxin-antitoxin (TA) systems were first identified as abortive infection systems wherein a phage infection causes altruistic suicide of the bacterium to prevent bacteriophage spread among its clonal ... -
Understanding Bacterial Heterogeneity in Gene Expression Under Specific and Global Regulatory Control
Intrinsic heterogeneity in natural bacterial populations enable them to escape sudden changes in environment and evolve. Processes like cellular crosstalk, abiotic interactors, host interactions, intracellular signalling ... -
Unravelling the spindle-independent function of cortical force-generating machinery (LIN-5/GPR-1/2) during cleavage furrow formation and abscission in C. elegans embryos
Cytokinesis marks the final stage of cell division, where a single mother cell divides into two daughter cells. This intricate process begins with the assembly of an actomyosin-based cleavage furrow at the equatorial ... -
Behavioral and Neural bases of Subcomponents of the Attentional Blink
Attention enables us to select relevant stimuli for enhanced sensory processing and decision-making. Yet, our ability to pay attention is severely capacity limited. This limitation is clearly revealed when we seek to perform ... -
The benefits and costs of flexible alternative reproductive tactics in Oecanthus henryi
Alternative reproductive tactics (ARTs) are distinct phenotypes that individuals of a species use to maximize reproductive success. This thesis investigates the persistence and adaptive value of flexible ARTs in male tree ... -
Role of Sirtuin6 in the maintenance of cardiac lysosomal homeostasis
The response to cardiac stress can be divided into two phases- an initial adaptive compensatory phase followed by a maladaptive decompensatory phase. Protein homeostasis in cardiomyocytes has been observed to behave ... -
Insights into ISWI group Chromatin Remodeler BAZ1A (bromodomain adjacent to zinc finger domain 1A): A Key Player of E2F transcription program in glioma
ISWI (Imitation Switch) family of chromatin remodeling complexes mobilize nucleosomes to control DNA accessibility, which manages various DNA template-associated processes like replication, transcription, and repair. ... -
Investigating the neural basis of spatial attentional components with probabilistic and reward cueing
We are constantly inundated with an abundance of sensory information. “Attention” enables the selection of relevant information and filtering out irrelevant information, to guide adaptive behavior. While attention can be ... -
Molecular Interactions Between SARS-CoV-2 Viral and Human Cellular Factors: Implications for Viral Infection, Replication, and Disease
The COVID-19 pandemic was this century's most significant global public health crisis. The causative agent was SARS-CoV-2, an enveloped, single-stranded positive-sense virus. As an obligate intracellular pathogen, SARS-CoV-2 ... -
Cyclic nucleotide-binding proteins in mycobacteria
Mycobacterium tuberculosis, one of the leading causes of death worldwide even today, employs the second messenger cAMP extensively for its pathogenicity and persistence. Intracellular and extracellular levels of cAMP in ... -
Elucidating the diverse functions of RGG-motif containing proteins
One year embargo upto 20/2/2026 RGG-motif containing proteins represent one of the major subsets of RNA-binding proteins characterized by the presence of RGG/RG repeats. These proteins have been associated with a wide ... -
Interaction of the TCP4 protein with other transcription factors and its effect on Arabidopsis shoot apex
The TEOSINTE BRANCHED1, CYCLOIDEA, PROLIFERATING CELL FACTORs (TCP) class of proteins are plant-specific transcription factors with a non-canonical basic helix-loop-helix (bHLH) domain involved in both DNA-binding and ... -
Role of HCN Currents (Ih) in Epileptiform Activity in Subicular Neurons
Subicular burst firing neurons are established as primary instigators of seizure onset and propagation in Temporal Lobe Epilepsy (TLE), a form of focal epilepsy that accounts for approximately 60% of all epilepsy cases in ... -
Theta modulated dynamics in the hippocampus and its inputs during spatial navigation
The hippocampus is crucial for spatial navigation and has been hypothesized to integrate sensory information and mnemonic cues about items and experiences within a spatial context to create memories. Area CA1 is the ... -
Characterizing the link between dynamics and function in proteins that violate the structure-function paradigm
The structure-function paradigm states that the three-dimensional structure of a protein is dictated by its amino acid sequence, which influences its function. However, this paradigm fails to explain the behaviour of ... -
Exploring the roles of nucleoid-associated protein HU and two of its interacting proteins in Mycobacterium tuberculosis pathogenesis
Embargo up to Jan 29, 2026 The genome in prokaryotes is restricted to a membrane-less compartment termed nucleoid. The genome is maintained in the compacted state within the nucleoid with the help of three key cellular ... -
Distinct extracellular signatures of active-dendritic chemical and electrical synapses differentially contribute to ripple-frequency oscillations
Extracellular field potentials across brain regions exhibit distinct signatures that depend on several region-specific attributes, including spatiotemporal patterns of afferent inputs, anatomical and physiological properties ...