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Biochemical And Functional Characterization Of Evolutionarily Conserved Metallophosphoesterases The 239FB/AB Family
(2010-12-30)
With the advent of large scale genome sequencing efforts along with more sophisticated methods of genetic mapping, a number of loci have been identified that are associated with human diseases. Intriguingly, many genes ...
Studies On The Expression Of The bgl Operon Of Escherichia Coli In Stationary Phase
(2010-03-19)
The bgl operon of Escherichia coli, involved in the uptake and utilization of aromatic β-glucosides salicin and arbutin, is maintained in a silent state in the wild type organism by the presence of structural elements in ...
Structure-Function Correlations In Aminoacyl tRNA Synthetases Through The Dynamics Of Structure Network
(2010-08-16)
Aminoacyl-tRNA synthetases (aaRSs) are at the center of the question of the origin of life and are essential proteins found in all living organisms. AARSs arose early in evolution to interpret genetic code and are believed ...
Selective Binding Of Meiosis-Specific Yeast Hop1 Protein, or Its ZnF Motif, To The Holliday Junction Distorts The DNA Structure : Implications For Junction Migration And Resolution
(2010-09-30)
Saccharomyces cerevisiae HOP1, which encodes a component of the synaptonemal complex, plays an important role in both gene conversion and crossing over between homologs, as well as enforces the meiotic recombination ...
Studies On DNA Mismatch Repair Nicking Endonucleases Of Haemophilus Influenzae And Neisseria Gonorrhoeae
(2010-01-01)
DNA mismatch repair ensures faithful transmission of genetic material from parents to progeny, which is required for the survival of the organism. The studies on E. coli MMR proteins have formed the basis for the study ...
Identification And Characterization Of A Virus Inducible Non Coding RNA (VINC)
(2010-12-29)
Non-protein coding eukaryotic genome sequences often referred to as junk DNA are estimated to encode several non-coding RNAs (ncRNAs) which may account for nearly 98% of all genomic output in humans. The output of such a ...
Identification Of Key DNA Elements Involved In promoter Recognition By Mxr1p , A key Regulator Of Methanol Utilisation Pathway In Pichia Pastoris
(2010-04-09)
The methylotrophic yeast Pichia pastoris is widely used for recombinant protein production due to its ability to grow to high cell densities as well as possession of an inducible methanol utilization pathway (MUT). The ...
Molecular Genetic Studies On Pre-mRNA Splicing Factors Of Fission And Budding Yeasts
(2010-10-05)
Nuclear pre-mRNA splicing proceeds via two mechanistically conserved consecutive trans-esterification reactions catalyzed by the spliceosome. The ordered coalescence of spliceosomal snRNPs and splicing factors on the ...
Translational Control Of p53 And Its Isoform By Internal Initiation
(2010-07-19)
Tumor suppressor p53, the guardian of the genome, has been intensely studied molecule owing to its central role in maintaining cellular integrity. While the level of p53 protein is maintained low in unstressed conditions, ...
Functional Analysis Of DdRpb4 And DdRpb7, Two Subunits Of Dictyostelium Discoideum RNA Polymerase II
(2010-04-06)
The process of eukaryotic transcription and its regulation has been an interesting area of research for decades. With more insights into the process of transcriptional regulation of genes, studies have revealed a ...