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Understanding the Functions of Nucleoid Associated Proteins in Mycobacterium tuberculosis
The prokaryotic genome, though lacks a membrane bound organelle for its housing, is restricted to only about 25% of the cytoplasmic space called the nucleoid. The dramatic compaction required for the genome to fit in is ...
The dual-targeting of Saccharomyces cerevisiae Pso2 into the nucleus and mitochondria is regulated by post-translational modifications: Implications for organelle-specific DNA repair
The repair of DNA interstrand crosslinks (ICLs) involves the concerted action of multiple DNA repair pathways. In eukaryotes, ICLs are sensed and repaired by replication-coupled or replication-independent mechanisms in ...
Homeostasis of cyclic-di-AMP in Mycobacterium smegmatis: Functional and structural contributions of c-di-AMP synthase (MsDisA) and hydrolase (MsPDE)
In bacteria, cyclic-di-nucleotide based second messengers regulate various physiological processes including the stress response. For the past decades, cyclic diadenosine monophosphate (c-di-AMP) has emerged as a crucial ...
Transcription termination in Mycobacteria
Transcription termination is one of the key events of gene expression that decides the boundary of the gene. Termination either before the stop codon or transcriptional read-through into the downstream gene both have ...
Understanding the Long-term Impact and Mechanism of Action of Endosulfan, an Organochlorine Pesticide on Fertility, Development and Growth of Mice
Endosulfan (ES) is one of the major broad-spectrum organochlorine pesticides
categorized as Class II (moderately hazardous) by WHO and Class I (highly acutely toxic) by
US Environment Protection Agency. Although the use ...
Structural insights into assembly and regulation of HigBA toxin-antitoxin system from Escherichia coli
In the last few decades, bacterial Toxin-antitoxin (TA) systems have been identified to play crucial roles in bacterial survival under stressful conditions and virulence. TA systems are pair of genetic elements where one ...
Understanding Nonhomologous DNA End Joining: Novel Insights Into Mechanism and Regulation
This study has provided new insights into the mechanistic details of NHEJ
and showed that DNA sequence around the break site can be a factor in determining which
proteins involved in NHEJ might be recruited with a higher ...
Mechanistic insights into the role of miR‐6741‐3p in oral squamous cell carcinoma pathogenesis
Many functional studies and clinical analysis have linked miRNA dysregulation as a causative factor for tumor initiation and progression. Overexpression of oncogenic miRNAs and downregulation of tumor suppressor miRNAs are ...
Mutational sensitivity of CcdB mutants in their native operonic context
Determining the precise effects of thousands of point mutants on protein structure, stability, and activity is a challenging task. Chapter 1 introduces how next-generation sequencing technologies exploit phenotypic screens ...
Unravelling the functional role of Arf-like GTPases 14 and 15 in mammalian cells
Small G-proteins of Arf-like (Arl) GTPase subfamily are shown to regulate several cellular processes including intracellular trafficking, cytoskeletal organization, organelle biogenesis, cell adhesion and migration. Around ...