Browsing Division of Biological Sciences by Subject "Research Subject Categories::NATURAL SCIENCES::Biology"
Now showing items 1-16 of 16
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Aβ42-mediated dendritic spine loss in an in-vitro model of Alzheimer’s disease
The results from this study establish the molecular mechanism underlying the Aβ42-mediated dendritic spine loss observed in the APP/PS1 mouse model of AD. Further, this study highlights the role of Aβ42 in altering the ... -
Biochemical, Genetic and Molecular characterization of TCP3 and TCP4 transcription factors in Arabidopsis thaliana
The TEOSINTE BRANCHED1, CYCLOIDEA, PROLIFERATING CELL FACTORs (TCP) family of proteins consists of plant-specific, non-canonical basic helix-loop-helix transcription factors that perform diverse developmental processes. ... -
Climate-Growth Relationships of West Himalayan Fir (Abies pindrow) along an Altitudinal Gradient in Northwestern Himalaya
Climate change which includes an increase in temperature, changes in precipitation, retreating of glaciers, has a significant impact on ecosystem dynamics and the social communities. High mountains around the globe are ... -
Computational investigation of peripheral membrane protein "Pleckstrin homology domain" and its regulation
The peripheral membrane protein repertoire is around 25% composed of the Pleckstrin homology domain (PHD). PHD are component of the multidomain protein and plays the role of an adaptor in recruitment of these proteins ... -
Computational studies on interacting proteins with special reference to toxin-antitoxin systems
Proteins interact with other proteins to maintain functional homeostasis of the cell by tightly regulating cellular processes. Hence, it becomes important to understand not only the downstream effects of protein-protein ... -
Estimation of the spatial spread of brain signals at multiple scales
Spatial spread of a particular brain signal can be defined as the area of the cortical tissue around the recording electrode that contributes to the electrical activity recorded by the electrode. More specifically, ... -
Glycobiological Regulation of Breast Cancer Invasion
Invasiveness of cancer is the predominant reason behind mortality associated with the disease. Although long under active investigation, fundamental aspects of the early steps of cancer invasion and metastasis are still ... -
The influence of landscape composition on butterfly populations: A behavioural ecological approach
Overall, taking behavioural ecological and trait-based approaches, my study suggests that the distribution of a species and patterns in its population densities in a landscape are affected by diverse ecological variables, ... -
Influence of the substrate specificity of Mycobacterium tuberculosis ClpX on the transcriptional profile
Cellular homeostasis in bacteria is maintained by diverse molecular machines. These include several one-component systems (OCS), two- component systems (TCS), chaperone proteins, proteases, proteolytic complexes and ... -
Local Interactions, Spatial Patterns and Ecosystem Stability
Many ecosystems exhibit striking patterns in the spatial distribution of organisms, for example, patterns of clumping and dispersion in semi-arid vegetation, mussel in intertidal beds and even sea-grass and macroalgae. ... -
Mechanistic insights into protein stabilization and protein-protein interactions
Most amino acid substitutions in a protein either lead to partial loss of function or are near neutral. Several studies have shown the existence of second-site mutations that can rescue the defects caused by diverse loss ... -
Qualitative similarities and differences between monkey and human visual perception
Animal models play a crucial role in helping neuroscientists unravel the computations supporting behaviour at the resolution of a single neuron in the brain. In vision science, the macaque monkey is the pre-eminent model ... -
Role of Mint family of Proteins in the nanoscale localization and real-time retention of surface Amyloid Precursor
Amyloid beta, a key determinant in the pathology of Alzheimer's disease (AD), is formed by the sequential proteolysis of Amyloid Precursor Protein (APP) by β-and γ-secretase. Evidence over the last few decades indicates ... -
Through the looking glass: Phoresy as seen in the light of mutualism
Phoresy is the dispersal of small organisms on larger ones to move out of an unfavourable habitat. Although these interactions are transient, they can form tight links with mutualistic interactions if the phoretic organisms ... -
Use of Human Induced Pluripotent Stem Cells as a Model to Study Primary Microcephaly
The aim of this study was to use human induced pluripotent stem cells (hiPSC) to understand key steps of neuronal differentiation and to model the human brain developmental disorder, primary microcephaly (MCPH). MCPH is a ... -
Use of sub-family specific residues of protein modules in recognizing sites of functional and structural specialization
Functional and regulatory features of a protein in a living system are determined by several factors such as chemical nature and three-dimensional arrangement of residues in the functional site, spatial and temporal ...