Browsing Division of Biological Sciences by Advisor "Surolia, Avadhesha"
Now showing items 1-20 of 22
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Biochemical And Molecular Insights Into β-Hydroxyacyl-Acyl Carrier Protein Dehydratase (FabZ) From Plasmodium Falciparum
(2008-10-14)Malaria, caused by Plasmodium, is one of the most devastating infectious diseases of the world in terms of mortality as well as morbidity (WHO, 2002). The development of resistance in the Plasmodium falciparum against the ... -
Components Of Fatty Acid Synthesis In Plasmodium Falciparum
(2008-10-17)The disease malaria afflicts more than a billion people and kills almost one to three million of them every year. Of the four species of Plasmodium affecting man viz., P. falciparum, P. vivax, P. ovale and P. malariae, ... -
Computational And Biochemical Studies On The Enzymes Of Type II Fatty Acid Biosynthesis Pathway : Towards Antimalarial And Antibacterial Drug Discovery
(2009-08-13)Malaria, caused by the parasite Plasmodium, continues to exact high global morbidity and mortality rate next only to tuberculosis. It causes 300-500 million clinical infections out of which more than a million people succumb ... -
Endotoxin Peptide/Protein Interactions: Thermodynamic And Kinetic Analysis
(Indian Institute of Science, 2006-05-15)Endotoxin or Lipopolysaccharide (LPS) is the invariant structural component of gram negative bacterial outer membranes and is the chief causative factor of Sepsis or endotoxic shock. Sepsis is a syndrome that has very high ... -
Energetics Of Protein-Carbohydrate Recognition
(Indian Institute of Science, 2006-04-28)The work embodied in this thesis pertains to an attempt to understand better, the molecular basis of protein-carbohydrate recognition. For this purpose a systematic study was undertaken, not only of the energetics of ... -
Folding Studies On Peanut Agglutinin : A Lectin With An Unusual Quaternary Structure
(2009-03-04)The thesis entitled “Folding studies on Peanut Agglutinin: A lectin with an unusual quaternary structure” deals with the several aspects of the folding of the tetrameric legume lectin Peanut Agglutinin ... -
Garlic (Allium Sativum) Agglutinin I: Specificity, Binding And Folding Mechanism
(Indian Institute of Science, 2006-11-08)Lectins are a class of proteins that bind to carbohydrates with a high degree of specificity. They are involved in various cellular processes such as, host - pathogen interactions, targeting of proteins within cells, cell ... -
Insights Into The Mechanistic Details Of The M.Tuberculosis Pantothenate Kinase : The Key Regulatory Enzyme Of CoA Biosynthesis
(2013-04-26)Tuberculosis (TB), caused by Mycobacterium tuberculosis, has long been the scourge of humanity, claiming millions of lives. It is the most devastating infectious disease of the world in terms of mortality as well as morbidity ... -
Mechanism Of Anticancer And Antimalarial Action Of A Modulator Of Heat Shock Proteins
(2007-11-16)This thesis entitled “Mechanism of Anticancer and Antimalarial Action of a Modulator of Heat Shock Proteins” describes the successful elucidation of the mechanism of anticancer and antimalarial action of 15-Deoxyspergualin ... -
Mechanistic And Regulatory Aspects Of The Mycobacterium Tuberculosis Dephosphocoenzyme A Kinase
(2013-09-11)The current, grim world-TB scenario, with TB being the single largest infectious disease killer, warrants a more effective approach to tackle the deadly pathogen, Mycobacterium tuberculosis. The deadly synergy of this ... -
Molecular Characterization of Mannose Binding Lectins
Lectins are proteins of non-immunologic origin that bind to carbohydrates with high fidelity. They constitute a large class of multivalent recognition molecules that specifically interact with their cognate sugar moieties ... -
Pranlukast as an Allosteric Inhibitor of M.Tuberculosis Ornithine Acetyltransferase : Implication Towards Novel Combinatorial Therapy
Tuberculosis (TB) is a deadly disease responsible for the death of approximately 1.5 million people each year, with the highest being from developing nations. Tuberculosis affects mostly the lungs, and other parts of the ... -
Role of autophagy in reducing peripheral neuropathy and diabetic peripheral neuropathy
Peripheral neuropathy occurs when there is damage to the central or peripheral nervous system due to injury, disease, diabetes, or drug use. Endoplasmic reticulum (ER) stress is a distinct feature observed in neuropathic ... -
Role of Glycosylation and Oligomerization on the Stability of Soybean Agglutinin
Carbohydrates are vital to life. In their naive form, they serve as a primary energy source for supporting life. However, in most cases carbohydrates do not exist as simple sugars in nature. Instead they occur as more ... -
Structural and Functional Characterization of Enzymes of Proline Biosynthesis Pathway in Mycobacterium tuberculosis
Tuberculosis is the second largest killer disease on global scale after HIVAIDS. The rapid evolution of Mycobacterium tuberculosis into drug resistant strains and the toxicity of these drugs are the major constraints in ... -
Structural Studies On Mycobacterium Tuberculosis Pantothenate Kinase (PanK)
(2011-07-18)Pantothenate kinase (PanK) is an ubiquitous and essential enzyme that catalyzes the first step in the universal Coenzyme (CoA) biosynthesis pathway. In this step, pantothenate (Vitamin B5) is converted to 4′-phosphopantothenate, ... -
Structural, Biophysical And Biochemical Studies On Mannose-Specific Lectins
(2013-01-17)For a long time, the scientific community underestimated the value of carbohydrates and the approach of most scientists to the complex world of glycans was apprehensive. The scenario, however, has changed today. With the ...