Browsing Division of Biological Sciences by thesis submitted date"2009"
Now showing items 21-40 of 48
-
Lip Y, The PE Family Triacylglycerol Hydrolase From Mycobacterium Tuberculosis : Functional Role Of The PE Domain And Immunogenicity
(2010-10-28)More human lives have been lost to tuberculosis than to any other disease and despite the availability of effective short course chemotherapy (DOTS) as well as the Bacilli Calmette Guerin (BCG) vaccine, tuberculosis continues ... -
Mechanism Of Ribosome Recycling In Eubacteria, And The Impact Of rRNA Methylations On Ribosome Recycling And Fidelity Of Initiation In Esherichia coli
(2009-12-09)The studies reported in this thesis address, firstly, aspects of ribosome recycling in eubacteria, and secondly, a preliminary characterization of an EFG-like locus from Mycobacterium smegmatis. A hitherto unsuspected role ... -
Molecular Genetic Analysis Of The Role Of Nse2, A SUMO E3 Ligase Of The Smc5/6 Complex, In Resisting Genotoxic Stress And Maintaining Chromosome Stability In Saccharomyces Cerevisiae
(2011-01-20)DNA repair pathways have evolved to protect the genome from damage caused by intrinsic and extrinsic factors. Although numerous DNA repair mechanisms have been studied and reported, information regarding how they coordinate ... -
Mycobacterium Smegmatis RecA And SSB : Structure-Function Relationships, Interaction With Cofactors And Accessory Proteins
(2011-04-06)Homologous genetic recombination, because of its fundamental roles in the maintenance of genome stability and evolution, is an essential cellular function common to all organisms. This process also plays important roles ... -
Newer Insights On Structure, Function And Regulation Of Dps Protein From Mycobacterium smegmatis
(2010-12-29)The first chapter will provide an introduction to the physiology, pathogenesis and biology of mycobacteria. Host-pathogen interactions, different modes of resistance of the bacteria, adaptations for survival under nutrient ... -
Peroxisomal Targeting Of Pichia Pastoris Cytochrome C During Methanol And Fatty Acid Metabolism
(2011-03-08)Intracellular protein sorting plays a key role in the regulation of cellular metabolism, gene expression, signal transduction and a number of other cellular processes. Proteins targeted to specific cellular compartments ... -
Regulation and Characterization of Transcription Factor Activator Protein-2 Alpha (AP-2α)
(2018-02-11)Introduction AP2α is a 52 kDa retinoic acid inducible and developmentally regulated activator of transcription, which binds to the DNA in a sequence-specific manner. Transcription factor AP-2α was isolated from HeLa cells ... -
Rinderpest Virus Transcription : Functional Dissection Of Viral RNA Polymerase And Role Of Host Factor Ebp1 In Virus Multiplication
(2009-11-23)Rinderpest virus (RPV) belongs to the order Mononegavirale which comprises non segmented negative sense RNA viruses including human pathogens such as Measles, Ebola and Marburg virus. RPV is the causative agent of Rinderpest ... -
Starvation Response In Mycobacterium Smegmatis : A Tale Of Two Proteins
(2010-10-19)The Dps (DNA-Binding Protein from Starved Cells) proteins are a class of stress-specific proteins with a major role in protecting DNA during the stationary phase of bacterial growth, through direct physical binding as well ... -
Stress Response In Salmonella And Its Role In Pathogenesis
(2011-02-08)Chapter: 1 Introduction Genus Salmonella is a Gram-negative rod shaped facultative anaerobic bacteria that can survive inside the host macrophages and cause persistent infection. Salmonella Typhimurium, Salmonella Typhi ... -
Structural And Biophysical Analysis Of The Regulatory Mechanism Of Mycobacterium Tuberculosis Sigma Factors
(2010-12-07)Mycobacterium tuberculosis has one ribosomal RNA operon. The survival of this bacillus thus depends on a transcription mechanism that can effectively couple gene expression to changes in the environment. σ factors are ... -
Structural And Functional Analysis Of Proteins With The Double Stranded β-helix (Cupin) Domains
(2010-12-24)Proteins performing catalytic roles predominantly occur in a few protein folds. Functional diversity within a common structural scaffold has been attributed to conformational features that enable exploration of reaction ... -
Structural Studies On Mycobacterial RecA And RuvA
(2010-10-21)Homologous recombination is a fundamental cellular process evolved to maintain genomic integrity and to generate genetic diversity. It plays a crucial role in DNA repair, correct segregation of meiotic chromosomes and ... -
Structural Studies On Physalis Mottle Virus Capsid Proteins & Stress Response Proteins Of Oryza Sativa And Salmonella Typhimurium
(2013-04-26)X-ray crystallography is one of the most powerful tools for the elucidation of the structure of biological macromolecules such as proteins and viruses. Crystallographic techniques are extensively used for investigations ... -
Structural, Functional And Transcriptional Analysis Of Nucleoside Diphosphate Kinase From Mycobacterium Smegmatis mc2 155
(2011-08-05)Maintenance of the levels of nucleoside triphosphates (NTPs) as well as their corresponding deoxy derivatives (dNTPs) is crucial to all growth and developmental processes. The enzyme nucleoside diphosphate kinase (NDK) ... -
Structure Function Relationship In Tryptophanyl tRNA Synthetase Through MD Simulations & Quantum Chemical Studies On Unusual Bonds In Biomolecules
(2010-10-21)Biological processes are so complicated that to understand the mechanisms underlying the functioning of biomolecules it is inevitable to study them from various perspectives and with a wide range of tools. Understanding ... -
Structure-Function Correlative Studies On The Biochemical Properties (Polymerisation, GTP binding, GTPase) Of Mycobacterial Cytokinetic Protein FtsZ In Vitro
(2010-03-26)FtsZ, the principal cell-division protein, polymerizes in GTP-dependent manner in vitro (Bramhill and Thompson, 1994; Mukherjee and Lutkenhaus, 1994; Rivas et al., 2000). FtsZ polymerization at the mid-cell site of bacterium ... -
Studies On DNA Mismatch Repair Nicking Endonucleases Of Haemophilus Influenzae And Neisseria Gonorrhoeae
(2010-01-01)DNA mismatch repair ensures faithful transmission of genetic material from parents to progeny, which is required for the survival of the organism. The studies on E. coli MMR proteins have formed the basis for the study ... -
Studies On Growth And Development Of The Ovarian Dominant Follicle In Monovulatory Species : Analysis Of Transcriptional Changes And Factors Influencing Periovulatory Events
(2010-10-28)In response to LH surge, the selected dominant follicle undergoes a series of complex events viz., meiotic maturation of the oocyte, terminal differentiation of follicular cells, cumulus expansion and follicular rupture ... -
Studies On Intracrine Regulators Of Ovarian Function : Examination Of Progesterone Action On Structure And Function Of Corpus Luteum In The Monkey
(2011-08-09)The control of reproductive cycles in higher primates is largely dependent on negative and positive feedback mechanisms by both steroidal and non-steroidal substances of the ovaries which regulate the function of ...