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Now showing items 6251-6270 of 6382
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Unraveling the Mechanism of Luteinizing Hormone Receptor Activation : Hinge Region as a Key Player
(2018-06-05)GPCRs, influencing myriads of cellular functions, are the members of the largest family of the membrane proteins. However, their structures and the signaling mechanisms still remain enigmatic. In case of the Glycoprotein ... -
Unraveling the multifaceted interactions between the tumor cell hierarchy and the stroma: Implications on tumor growth
In this study, we have functionally characterized the roles of SEZ6, a GSC-specific protein, and FMOD, a DGC-specific protein, in inducing tumor angiogenesis. Angiogenesis being a crucial requirement for both tumor initiation ... -
Unraveling the role of cellular phosphatases in lysosome function and storage diseases
Eukaryotic cellular pathways are maintained and coordinated through biomolecule turnover, which includes synthesis, trafficking, degradation of cellular components and their reutilization. The process of biomolecule ... -
Unravelling the composition space of Zr2FeNiSb2 double half-Heusler thermoelectric material
More than half of annual energy consumption in thermal power plants are released in the form of waste heat. However, this waste heat could be harnessed with the help of thermoelectric (TE) devices which can convert this ... -
Unravelling the functional role of Arf-like GTPases 14 and 15 in mammalian cells
Small G-proteins of Arf-like (Arl) GTPase subfamily are shown to regulate several cellular processes including intracellular trafficking, cytoskeletal organization, organelle biogenesis, cell adhesion and migration. Around ... -
Unravelling the kinematics, dynamics and structure of galaxies using H I - 21cm observation
The advent of the multi-wavelength observations of galaxies in this recent era gives us the opportunity to study the details of the different pivotal facets of galactic astrophysics. Among the observations in different ... -
Unravelling the Mechanism of Bactericidal/Permeability-Increasing Protein Expression during Bacterial Pathogenesis
(2018-02-21)Anti-microbial proteins (AMP) are the key effector arm of the innate immune system. The prevalence of AMP in single-celled eukaryotes to humans shows its importance during the course of evolution. The first report for the ... -
Unravelling The Mechanisms Of Myofibrillogenesis And Human Myopathies Using Drosophila Mutants
(2013-07-18)Myofibrillogenesis is a complex process, which involves assembly of hundreds of structural proteins in a highly ordered manner to form the contractile structural unit of muscle, the sarcomere. Several myopathic conditions ... -
Unravelling the Nature of Halogen and Chalcogen Intermolecular Interactions by Charge Density Analysis
(2018-07-20)The thesis entitled “Unravelling the Nature of Halogen and Chalcogen Intermolecular Interactions by Charge Density Analysis" consists of five chapters. A basic introductory section describes the topics relevant to the work ... -
Unravelling The Regulators Of Translation And Replication Of Hepatitis C Virus
(2013-06-07)Unravelling the regulators of translation and replication of Hepatitis C virus Hepatitis C virus (HCV) is a positive sense, single stranded RNA virus belonging to the genus Hepacivirus and the family Flaviviridae. It ... -
Unsteady Flow Field Downstream Of A Sudden Expansion
(2009-04-02)Separating and reattaching flows are important in a large number of engineering configurations. The flow through a sudden expansion (backward-facing step) represents a conceptually simple case of this class of flows and hence ... -
Unsteady Two Dimensional Jet with Flexible Flaps at the Exit
(2017-11-13)The present thesis involves the study of introducing passive exit flexibility in a two dimensional starting jet. This is relevant to various biological flows like propulsion of aquatic creatures (jellyfish, squid etc.) and ... -
Untangling the Helicobacter pylori genome: Deciphering the significance of zinc finger motif(s) in Topoisomerase I catalysis
Helicobacter pylori, a human pathogen dominating gastric microbial population, displays differential gene expression during various stages of stomach colonization. Topoisomerases play a crucial role in maintaining DNA ... -
Unusual Acylation Properties Of Type II Fatty Acid Biosynthesis Acyl Carrier Proteins
(2010-07-06)This thesis entitled ‘ Unusual Acylation Properties of Type II Fatty Acid Biosynthesis Acyl Carrier Proteins’ describes the discovery of self-acylation and malonyl transferase activity in acyl carrier proteins involved in ... -
Upper Bound Finite Element Limit Analysis for Problems of Reinforced Earth, Unsupported Tunnels and a Group of Anchors
(2017-11-27)This thesis presents the implementation of the upper bound limit analysis in combination with finite elements and linear optimization for solving different stability problems in geomechanics under plane strain conditions. ... -
Upper Frequency Bound on Circuit-Based Models for Transformer Windings
The power generation, transmission and utilisation are necessarily being carried out at different voltage levels, and require transformers for performing the voltage level conversions. As a result, transformers form one ... -
Urbanisation and Shifting Phenotypes Behavioural, Physiological and Cognitive Strategies of the Indian Rock Agama Psammophilus Dorsalis
(2018-07-09)Humans directly or indirectly cause changes in the environment, and urbanisation is currently one of the most important threats to biodiversity. Urbanisation exposes organisms to novel pressures that are drastically different ... -
Urolithin-A mitigates synaptic dysfunctions associated with epilepsy through VDAC1 inhibition: A novel therapeutic approach
Urolithin-A mitigates synaptic dysfunctions associated with epilepsy through VDAC1 inhibition: A novel therapeutic approach Epilepsies are a group of neurological disorders with a prevalence of 70 million people worldwide ...