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Now showing items 4351-4370 of 6382
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Protein Engineering and Stabilization of HIV-1 Envelope Glycoprotein
(2018-05-09)A number of viral diseases such as Hepatitis B, small pox, measles, rubella and polio have effective vaccines to control or eradicate them. HIV-1 is a lentivirus which infects human immune cells and leads to the disease ... -
Protein Engineering of HIV-1 Env and Human CD4
(2018-05-01)Since, its discovery over three decades ago, HIV has wrecked havoc worldwide. According to the UNAIDS report 2011, at present 34 million people is living with HIV and AIDS vaccine with broadly neutralizing activity still ... -
Protein Folding, Function and Aggregation Role of Co-solvents and Topological Frustration
Proteins are biological macromolecules formed by sequentially joining natural amino acids through peptide bonds. The sequence of amino acids in a protein chain determines its three dimensional structure under physiological ... -
Protein NMR Studies of E. Coli IlvN and the Protease-VPg Polyprotein from Sesbania Mosaic Virus
(2018-04-03)Acetohydroxyacid synthase is a multisubunit enzyme that catalyses the first committed step in the biosynthesis of the branched chain amino acids viz., valine, leucine and isoleucine. In order to understand the structural ... -
Protein Structure and Mutant Phenotype Prediction from Analysis of Mutant Libraries by Deep Sequencing
Proteins play a central role in all the biological processes. The immense diversity in protein structures and functions despite similar underlying composition is intriguing. The work presented in this thesis aims to provide ... -
Protein-DNA Graphs And Interaction Energy Based Protein Structure Networks
(2013-01-29)Proteins orchestrate a number of cellular processes either alone or in concert with other biomolecules like nucleic acids, carbohydrates, and lipids. They exhibit an intrinsic ability to fold de novo to their functional ... -
Protein-Nanomaterial Interactions: Structural And Dynamic Aspects
Owing to their unique properties, the noble metallic nanoparticles and graphenic nanomaterials find their applications in diverse fields of science. Particularly in the field of biomedicine, nanomaterials are being used ... -
Protein-small molecule interactions: Structural insights and applications in computational drug discovery
Deviation from normal healthy conditions, termed as disease, can often be triggered due to the malfunctioning of proteins. Modulating the functions of proteins by administering therapeutic agents (drugs) may alleviate the ... -
Proteomic Approaches to Study Glioma Development, Progression and Therapy
(2018-04-02)Astrocytoma, the tumor of astrocytic origin, accounts for about 60 % of the primary brain tumors. As per World Health Organization grading system, astrocytoma is classified as circumscribed astrocytoma (Grade I; pilocytic ... -
Proteomics-based Identification of Serum Biomarkers : Role of Secreted MCSF and CRP in Glioma Pathogenesis
Gliomas are the neoplasia of glial cells present in the brain and comprises of more than 70% of all the neoplasms of the central nervous system. They consist of a family of primary brain tumors that are categorized based ... -
Protocols for quantum information processing on graph states
Quantum entanglement is a unique phenomenon that occurs in quantum systems and ensures the feasibility of tasks considered impossible in the classical world. Two such important tasks are superdense coding and quantum ... -
Proton kinetic energy anomaly, Kauzmann temperature for nanoconfined water and design of nanoscale membrane for water desalination.
Structure, dynamics and thermodynamics of water molecules con fined inside the nanopores of various geometries are of fundamental interest owing to their potential applications in various nanofluidic devices, such as ... -
Provable Methods for Non-negative Matrix Factorization
(2017-10-31)Nonnegative matrix factorization (NMF) is an important data-analysis problem which concerns factoring a given d n matrix A with nonnegative entries into matrices B and C where B and C are d k and k n with nonnegative ... -
Provably Convergent Algorithms for Denoiser-Driven Image Regularization
Some fundamental reconstruction tasks in image processing can be posed as an inverse problem where we are required to invert a given forward model. For example, in deblurring and superresolution, the ground-truth image ... -
Providing QoS To Real-time And Data Applications In 3G Wireless Systems
(2010-07-29)In this thesis we address the problem of providing end-to-end quality of service (QoS) to real-time and data connections in a third generation (3G) cellular network based on the Universal Mobile Telecommunication System ... -
Pseudo-binary and Pseudo-ternary diffusion couple methods for understanding the growth of interdiffusion zone between bond coat and superalloys
Ni-based superalloys are widely used in jet engine applications. Bond coats are applied to these alloys for protection during service in a very harsh environment at high operating temperature. The addition of Pt to the ... -
Psychographic Segmentation of Retail Banking Customers of Karnataka (India) - An Exploratory Study
Post Liberalization, India has witnessed a good growth rate in economy. The GDP has grown by in the range of 7- 8 percentage annually. The job prospects in India have increased phenomenally due domestic business climate ...