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Now showing items 2067-2086 of 5059
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Initiation of protein synthesis : Role of the three consecutive GC base pairs in the anticodon stem of initiator tRNAs
The presence of the three consecutive GC base pairs in the anticodon stems of the initiator tRNAs (3GC base pairs) are a highly conserved and a vital feature of the initiator tRNAs in all the domains of life. How this ... -
Innovative Optimal Guidance of Spacecrafts for Soft-Landing on Atmosphere-less Celestial Bodies
Nonlinear trajectory optimization based optimal guidance schemes are presented in this thesis for soft-landing of spacecrafts on atmosphere-less celestial bodies. First, a pseudo-spectral philosophy based multi-phase ... -
Insight into luteolytic effects of repeated administration of LH in pregnant rats: Analysis of cAMP/PKA pathway during LH-induced luteolysis
The Corpus luteum (CL) is a dynamic endocrine structure that develops in the ovary from the remnants of the ovulated follicle and plays a critical role in the control of estrous/menstrual cycle as well as in establishment ... -
Insights into an Evolutionary Radiation : Causes And Consequences of Diversification in the Western Ghats Bush Frogs
(2017-10-26)One of the biggest attractions of the tropics is its stunning diversity; the origin and determinants of this diversity are amongst the most important questions in evolution and biogeography. There are two ways of looking ... -
Insights Into Cytostatic Mechanisms Regulated By Receptor Guanylyl Cyclase C
(2016-11-16)All cells are equipped to sense changes in their environment and make adaptive responses according to the stimuli. Signal recognition usually occurs at the cell membrane (with the exception of steroid signalling) where the ... -
Insights into Differentiation of Mouse Pluripotent Stem Cells to Neural Lineage
(2017-12-10)Pluripotent stem cells (PSCs: ESCs and iPSCs) provide an excellent model system for studying neural development and function. These cells also serve as a reliable source of cell replacement for the treatment of various ... -
Insights into Differentiation of Pluripotent Stem Cells to Cardiac Progenitors and Cardiomyocytes
The mammalian heart is the first organ formed during development. It forms the crux of the circulatory system of the body and pumps blood (and therefore, nutrients) to all parts of the body. The continuous functioning of ... -
Insights into Instabilities in Burning and Acoustically Levitated Nanofluid Droplets
(2018-07-16)The complex multiscale physics of nanoparticle laden functional droplets in a reacting environment is of fundamental and applied significance for a wide variety of applications ranging from thermal sprays to pharmaceutics ... -
Insights Into Molecular Regulation Of Cardiomyocyte Differentiation Of Mouse Pluripotent Stem Cells
(2015-08-03)Pluripotent stem cells (PSCs) are specialized cells, which have remarkable ability to maintain in an undifferentiated state and are capable of undergoing differentiation to three germ-layer lineage cell types, under ... -
Insights into Network Coding Using Tools From Linear Algebra and Matroid Theory
Traditionally, the transmission of information through a network was carried out using store-and-forward techniques. This entails managing information bits in a network analogous to commodity flow, without mixing or combining ... -
Insights into Occurrence and Divergence of Intrinsic Terminators and Studies on Rho-Dependent Termination in Mycobacterium Tuberculosis
(2018-04-11)Two mechanisms, intrinsic and factor-dependent, have evolved for accomplishing the termination of transcription in eubacteria. In this thesis, the first chapter is an introduction to the topic that presents what is known ... -
Insights Into Oxidative Folding Of Retinol Binding Protein In The Endoplasmic Reticulum : A Study In Isolated Microsomes
(2009-04-30)The central role played by the Endoplasmic Reticulum (ER) in the correct folding and assembly of secretary and membrane proteins cannot be overstated. As the first compartment in the secretary pathway, it is responsible ... -
Insights into Substrate Specificity in Sortase Enzymes from Structural Studies on a Novel Class of Housekeeping Sortase (SrtE) Identifying Functionally Important Cis-Peptide Containing Segments in Proteins and their utility in Molecular Function Annotation
(2018-02-21)Understanding protein function is fundamental to the fields of protein engineering and drug design. While most of the previous efforts in this direction have focused on the sequence-structure-function paradigm, recent ... -
Insights into the Chemistry of Iron Complexes as Imaging and Photocytotoxic Agents
(2018-06-23)The current thesis addresses the various facets of the chemistry of photocytotoxic iron complexes including their syntheses, characterization, evaluation of the anti-proliferative activities in various cancer cell lines ... -
Insights Into The Contribution Of Hfq In Salmonella Pathogenesis : Possible Role In Immune Evasion And Vaccine Development
(2014-10-07)Chapter I Introduction Salmonellae are facultative Gram-negative intracellular pathogens. Different serovars of it causes a variety of diseases in multiple hosts with different disease outcomes. Salmonella enterica serovar ... -
Insights into the Influence of Electric Field on the Structural Evolution and its Correlation with the Properties in the Lead-based BiScO3-PbTiO3 and the Lead-free Na0.5Bi0.5TiO3 based Piezoceramics
Advanced piezoelectric ceramics are widely used as piezoelectric sensors, transducers, actuators, etc. Among the commercially viable piezoelectric systems, lead zirconate titanate, PbZr1-XTiXO3 (PZT) has dominated the ... -
Insights Into The Mechanism Of Actions Of Luteinizing Hormone And Prostaglandin F2α In The Regulation Of Corpus Luteum Function Of Monoovulatory Species
(2016-11-11)Corpus luteum (CL), a transient endocrine structure formed from the ruptured ovarian follicle after ovulation, secretes progesterone (P4) that is essential for establishment and maintenance of pregnancy in mammals. The ... -
Insights Into The Mechanism Of Polyprotein Processing Of Sesbania Mosaic Virus And Characterization Of The Polyprotein Domains
(2013-06-10)1. Viruses are obligate parasites that hijack the host cell machinery to synthesize their own gene products and for their propagation. In order to establish a successful viral infection, viruses have evolved different ... -
Insights Into The Mechanistic Details Of The M.Tuberculosis Pantothenate Kinase : The Key Regulatory Enzyme Of CoA Biosynthesis
(2013-04-26)Tuberculosis (TB), caused by Mycobacterium tuberculosis, has long been the scourge of humanity, claiming millions of lives. It is the most devastating infectious disease of the world in terms of mortality as well as morbidity ...