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Understanding the role of paraspeckle components NEAT1 and PSPC1 in HCV life cycle and pathogenesis
Hepatitis C virus (HCV) is an enveloped, small, icosahedral, positive-sense single-stranded RNA virus that belongs to the Hepacivirus genus and the Flaviviridae family. HCV causes acute and chronic hepatitis which can range ... -
Understanding the Role of Rab22A in Recycling Endosome Biogenesis and Melanocyte Pigmentation
(2018-08-28)Recycling embosoms (REs) are transient intermediates of endosomal network, constantly generated from early/sorting endosomes (EEs/SEs). Conventionally, these organelles function in recycling of many growth/nutrient/signalling ... -
Understanding the Role of SIRT2 in Cardiac Hypertrophy, Cell Death and Glucose Homeostasis
Over the last century the major causes of human deaths and ailments has shifted from acute infectious diseases to chronic aging related disorders like cancer and type-2 diabetes. The aging process is a universal property ... -
Understanding the Role of ThiJ/DJ-1/PfpI Family Member Proteins in Regulating Redox Homeostasis, Mitochondrial Health and Lifespan in Saccharomyces cerevisiae
In a healthy cell, the ROS levels are stringently regulated by the action of various enzymatic or non-enzymatic antioxidant systems. Imbalance in the ROS homeostasis generates oxidative stress resulting in damage to cellular ... -
Understanding the Role of ZCF32, a Zinc Cluster Transcription Factor, in Candida albicans Biology
(2018-05-25)As a human fungal pathogen, Candida albicans can cause a wide variety of disease conditions ranging from superficial to systemic infections. Many of these infections are caused by an inherent ability of the pathogen to ... -
Understanding the Sequence Dependence of NHEJ Mediated Double-strand Break Repair, and Identification of Novel DNA Ligase Inhibitors and their Potential Use as Cancer Therapeutics
Repair of DNA breaks is essential for maintenance of genomic integrity. DNA double-strand breaks (DSBs) are considered as the most harmful DNA lesions within the cells which if left unrepaired or are misrepaired, can lead ... -
Understanding the Significance of Ydcp, a Putative Peptidase Encoding Gene, in Virulence of Salmonella
Salmonella is a recognised enteric pathogen which infects several mammalian and avian hosts through faeco-oral route and establishes either a localised gastrointestinal inflammation and diarrhoea or a systemic fever, ... -
Understanding the SNARE Dynamics During Melanosome Biogenesis
(2018-08-11)Melanosome biogenesis is a highly regulated endosomal maturation process wherein structural fibers harbouring immature melanosomes acquires its biosynthetic proteins through the secretory pathway and finally matures into ... -
Understanding The Solar Magnetic Fields :Their Generation, Evolution And Variability
(2010-03-24)The Sun, by the virtue of its proximity to Earth, serves as an excellent astrophysical laboratory for testing our theoretical ideas. The Sun displays a plethora of visually awe-inspiring phenomena including flares, ... -
Understanding the structural organization of the carrier translocase machinery in regulating mitochondrial biogenesis and organelle quality control
Mitochondria are essential eukaryotic organelles required for diverse cellular functions including, energy homeostasis, iron-sulfur cluster biogenesis, and signaling. Therefore, the maintenance of organelle quality control ... -
Understanding the Structure, Bonding and Reactivity of Unsaturated Metallacycles : A Computational Study
(2018-04-05)Stabilization of highly strained organic species and altering normal reactivity norms of organic fragments by transition metals have been a triumphing feat of organometallic chemistry. A variety of saturated and unsaturated ... -
Understanding the vertical structure of galactic stellar disc and the role of interstellar gas and dark matter halo
The aim of this thesis is to understand the dynamical effect of interstellar gas and dark matter halo on the vertical distribution of stars in our Galaxy as well as modeling the stellar distribution in a generalized and ... -
Understanding Ultrafast Molecular Structural Dynamics in Liquids : Ultrafast Raman Loss and Transient Absorption Study
The present thesis deals with the detailed ultrafast experimental studies on the ex-cited state vibrational dynamics of model chemical systems in condensed phase. The molecular systems are studied by means of Ultrafast ... -
Underwater Acoustic Communications: Algorithms for Delay-Scale Spread Wideband Channels
In wideband wireless communication systems, the relative motion of the transmitter, receiver, or scatterers in the medium causes the Doppler effect, which stretches or compresses the transmitted waveforms, resulting in ... -
Unfolded Protein Response in Malaria Parasite
(2018-01-28)Plasmodium falciparum is responsible for the most virulent form of human malaria. The biology of the intra-erythrocytic stage of P. falciparum is the most well studied as it is this stage that marks the clinical manifestation ... -
Unfolding Operators in Various Oscillatory Domains : Homogenization of Optimal Control Problems
(2018-06-13)In this thesis, we study homogenization of optimal control problems in various oscillatory domains. Specifically, we consider four types of domains given in Figure 1 below. Figure 1: Oscillating Domains The thesis is ... -
Unfolding the Mechanism of Notch1 Receptor Activation : Implications in Cancer Stem Cell Targeting
(2018-05-01)Notch receptors and ligands are single-pass transmembrane proteins which play important roles in cell-cell communication. Notch in ‘harmony’ with other signaling pathways regulate the entire diversity of metazoan life ... -
Uniaxial Fatigue Behavior of Freestanding Platinum-Aluminide (PtAl) Bond Coat
Pt-aluminide (PtAl) bond coat is used as a part of Thermal Barrier Coating (TBC) system on Ni-base superalloy components in advanced gas turbine aeroengines. The thickness of B2-NiAl intermetallic based diffused coating ... -
Unidirectional High-Frequency-Link DC to Three-Phase AC Conversion: Topology, Modulation and Converter Design
In recent years, stringent restrictions on greenhouse gas emission due to the present global warming scenario is driving governments and power utilities worldwide behind electricity generation using renewable energy ... -
A Unified Approach to Quantitative Software Lifecycle Modeling
(Indian Institute of Science, 2005-04-06)An evolutionary process currently taking place in engineering systems is the shift from hardware to software where the role of software engineering is becoming more central in developing large engineering systems. This ...