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Now showing items 6209-6228 of 6419
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Understanding High Speed Mixing Layers with LES and Evolution of Urans Modeling
(2017-11-15)This thesis is concerned with studies on spatially developing high speed mixing layers with twin objectives: (a) to provide enhanced and detailed understanding of spatial development of two-dimensional mixing layer emanating ... -
Understanding in vivo Significance of Allosteric Regulation in mtHsp70s : Revealing its Implications in Parkinson's Disease Progression
(2018-01-28)Mitochondria are essential eukaryotic organelles, acting as the sites for numerous crucial metabolic and signalling pathways. The biogenesis of mitochondria requires efficient targeting of several hundreds of proteins from ... -
Understanding intramolecular signal transduction in regulated proteases of the High Temperature Requirement A family
Protein homeostasis in all organisms is a complex process involving regulatory mechanisms that govern protein synthesis, post-translational events and degradation. The protein degradation mechanism serves multiple functions ... -
Understanding Knowledge Needs And Processes In Design
(2011-01-31)In this knowledge economy, organizations are leveraging their competence through the knowledge they possess. Managing knowledge will potentially retain the competence held by the organization if knowledge generated across ... -
Understanding mRNA fate regulation by RGG motif protein, Sbp1
Cellular events that rely on translation regulation has been well established, however the molecular details of factors involved in bringing translation control remains inadequately explored. RNA binding proteins form ... -
Understanding Multi-Wavelength Signatures of Galactic Outflows Through 3-D Simulations
Evolution of galaxies is a phenomenon that affects the formation and composition of galaxies, and the intergalactic medium. It is mediated by processes that establish a symbiotic relationship between a galaxy and the ... -
Understanding Nonhomologous DNA End Joining: Novel Insights Into Mechanism and Regulation
This study has provided new insights into the mechanistic details of NHEJ and showed that DNA sequence around the break site can be a factor in determining which proteins involved in NHEJ might be recruited with a higher ... -
Understanding Nucleic Acid Charge Transport Properties using Multiscale Modelling Techniques
Understanding charge transport in molecular systems is of fundamental interest in rapidly growing field of molecular electronics as well as to understand biological signal transfer processes which are accompanied by the ... -
Understanding Patterns of Bird Species Distribution in the Western Ghats
(2018-06-23)Macroecology is the study of relationships between organisms and the environment at large spatial and temporal scales. This field of research examines patterns in species abundance, distribution and diversity. Understanding ... -
Understanding Phage MU Mom Regulation and Function
(2018-06-11)Mu is a temperate bacteriophage which infects Escherichia coli and several other Gram negative enteric bacteria. It is an extraordinary phage in several respects and has carved a special niche for itself both as a genetic ... -
Understanding protein structural excursions using residue networks and implications on biological function
The information required for a protein structure to fold into the native conformation is encoded in its sequence. Studying protein structures help to understand their biological function. Molecular interactions between ... -
Understanding quantitative process physics of 3D binderjet printing with validation in Ti-6Al-4V and inkjet bioprinting of mammalian cells
In the field of additive manufacturing, laser or electron beam based 3D printing is widely investigated for biomedical applications. However, much less explored is the binderjet 3D printing, which allows processing of ... -
Understanding Rules of Assembly and Species Interactions in Mixed-species Bird Flocks
In mixed-species bird flocks (flocks hereafter), participants vary in their degree of similarity with each other. Flock participants can gain group size (supplementary) benefits by choosing similar flock partners, or ... -
Understanding Solvent Effect On Triplet State Structure Of Thioxanthone And Its Derivatives Using Time-Resolved Resonance Raman Spectroscopy
(2014-05-01)It has long been recognized that course and efficiency of a chemical reaction is largely mediated by the short-lived transient species (excited state or radicals) which are formed as reactive intermediates during a chemical ... -
Understanding spontaneous emission in the strong coupling regime of an emitter and absorbing matter
This thesis proposes a partition of optical states into radiative and non-radiative parts when an emitter is proximal to resonant absorbing nanostructures. The conventional partition is valid only for the weak coupling ... -
Understanding Structure And Growth Of Physisorbed Films : A Combined Atomic Force Microscopy And Modeling Study
(2014-10-16)Surface modification has wide ranging implications in lubrication, microelectromechanical systems (MEMS), colloidal systems and biological membranes. Surface modification plays an important role in stabilizing gold ... -
Understanding structure, function, and dynamics in macromolecular complexes
In the scope of my thesis work, a concerted effort was undertaken to elucidate bi- ological functions through the lens of structural analysis, employing protein dy- namics. The role of protein dynamics in shaping and ... -
Understanding the adaptive responses of Salmonella Typhimurium during bile stress
Salmonella Typhimurium (S. Typhimurium) is an enteric pathogen that causes gastroenteritis. Although gastroenteritis is usually non-life threatening in healthy adults, it can cause fatality in children and immunocompromised ... -
Understanding the architecture of mitochondrial presequence translocase machinery and its implications in ALS progression
The current thesis describes the structural organization of the presequence translocase machinery and its functional association with ALS pathogenesis. The TIM23 complex is essential for the mitochondrial biogenesis of ... -
Understanding the Behavior of the Sun's Large Scale Magnetic Field and Its Relation with the Meridional Flow
(2018-07-05)Our Sun is a variable star. The magnetic fields in the Sun play an important role for the existence of a wide variety of phenomena on the Sun. Among those, sunspots are the slowly evolving features of the Sun but solar ...