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Structural and DNA binding properties of ARID domains present in hSWI/SNF chromatin remodeling complex subunits
The SWI/SNF complexes are multisubunit-containing protein complexes that are involved in chromatin-remodeling processes in the eukaryotic cells. In higher eukaryotes, SWI/SNF complexes contain one or more mutually exclusive ... -
Structural and Dynamic Studies of Protein-Nanomaterial Interactions
(2017-11-28)My thesis is divided into five chapters, starting with a general introduction in first chapter and sample preparation and protein-NMR assignment techniques in second chapter. The remaining three chapters focus on three ... -
Structural and Electrochemical Investigation of Bisulfate and Hydroxysulfate based Polyanionic Cathodes
The discovery of LiFePO4 cathode for Li-ion battery ushered intensive study on polyanionic high-voltage battery insertion materials. Polyanionic materials offer rich crystal chemistry, robust framework, voltage tunability, ... -
Structural and Electrochemical Investigation of Fluoro(hydroxy)phosphate Based Cathode Materials for Secondary Batteries
Structural and electrochemical investigation of LiFePO4OH hydroxyphosphate material. The synthesis and structure of this material is explained. The hydrothermally synthesized material crystallizes in triclinic structure ... -
Structural and Electrochemical Investigations of Monovalent and Divalent Aqueous Rechargeable Batteries
Several stringent laws and regulations have been enforced by various National/International agencies for the adoption of sustainable methods for energy production and usage. In recent times, electric grids based on alternative ... -
Structural and Evolutionary Analyses of Signalling Proteins with Special Reference to Protein Kinases
(2018-02-27)Cellular response to environmental changes involves a wide repertoire of complex signalling systems often resulting in up and down regulation of various genes. These mechanisms are generally conserved in a variety of ... -
Structural And Evolutionary Studies On Protein-Protein Interactions
(2014-05-27)The last few decades have witnessed an upsurge in the availability of large-scale data on genomes and genome-scale information. The development of methods to understand the trends and patterns from large scale data promised ... -
Structural and Functional Analysis of Proteins involved in Microbial Stress Tolerance and Virulence
(2018-08-11)The genus Salmonella consists of pathogenic gram negative organisms which infect intestines of birds, animals and humans. They are the causative agents of salmonellosis which is characterised by diarrhoea, nausea, fever ... -
Structural And Functional Analysis Of Proteins With The Double Stranded β-helix (Cupin) Domains
(2010-12-24)Proteins performing catalytic roles predominantly occur in a few protein folds. Functional diversity within a common structural scaffold has been attributed to conformational features that enable exploration of reaction ... -
Structural and Functional Characterisation of Small Heat Shock Protiens from Mycobacterium Marinum M
Small Heat Shock Proteins (sHSP) are ATP-independent molecular chaperones that exhibit diversity in structure, function and mode of action. They are present ubiquitously in all kingdoms of life. They function mainly by ... -
Structural And Functional Characterization Of Calcium-Dependent Protein Kinase (CaCDPK1) From Cicer Arietinum : Effects Of Autophosphorylation And Membrane Phospholipids
(2016-07-11)In plants, calcium is a ubiquitous signaling molecule and changes in cytosolic calcium levels reported in response to various abiotic and biotic stresses like salt stress, drought, pathogen attack and phytohormone signaling. ... -
Structural and Functional Characterization of Enzymes of Proline Biosynthesis Pathway in Mycobacterium tuberculosis
Tuberculosis is the second largest killer disease on global scale after HIVAIDS. The rapid evolution of Mycobacterium tuberculosis into drug resistant strains and the toxicity of these drugs are the major constraints in ... -
Structural and Functional Characterization of Quadruplex DNA Structures in Human Acetyl-CoA Carboxylase 1 Gene Promoters and Stabilization of G-quadruplex DNA by Carbazole-benzimidazole Conjugates
A number of studies have established that DNA targeting is a successful strategy in anticancer therapy. In recent years, however, the focus has shifted from double-stranded DNA to alternative DNA motifs such as G-quadruplex ... -
Structural and functional insights into hybrid AT-less megaenzyme synthase (NRPS) and DNA-MsDps2 complexes using single particle cryo-EM
Microorganisms, mainly bacteria and fungi, are the producers of structurally diverse, complex organic compounds called as secondary metabolites. These metabolites include polyketides (PKs), non-ribosomal peptides (NRPs), ... -
Structural and functional insights into hybrid AT-less megaenzyme synthase (NRPS) and DNA-MsDps2 complexes using single particle cryo-EM
Microorganisms, mainly bacteria and fungi, are the producers of structurally diverse, complex organic compounds called as secondary metabolites. These metabolites include polyketides (PKs), non-ribosomal peptides (NRPs), ... -
Structural and functional insights of biological macromolecules associated with infectious diseases – single particle cryo-electron microscopy based studies
In the global context, particularly in India, the two most important infectious diseases among many others are Tuberculosis (TB), an age-old disease and COVID-19, a new-age disease. This thesis focuses on some of the key ... -
Structural and Functional Investigation of a Multi-drug Efflux Transporter QacA
The emergence of multi-drug resistance in bacteria is a global health care challenge. One of the effective means of gaining antimicrobial resistance, among superbugs, is through expression of efflux pumps. Quaternary ... -
Structural and functional studies on a small Heat Shock Protein from Entamoeba histolytica
Small Heat Shock Proteins (sHSPs) are molecular chaperones that bind to unfolding proteins during cellular stress to prevent them from aggregation. Once the normal conditions are restored, sHSPs release the bound substrate ...