Browsing by Title
Now showing items 4695-4714 of 8871
-
Molecular Characterization Of The SLC22A18AS Gene From The Imprinted Human Chromosome Segment 11p15.5
(2011-02-21)The imprinting status of the SLC22A18AS gene, located in the human chromosome segment 11p15.5, was studied using PCR-SSCP analysis and fetal tissues from a battery of 17 abortuses. This gene showed monoallelic expression ... -
Molecular Cloning And Characterization Of A Calcium-Depdendent Protein Kinase Isoform ScCPK1 From Swainsona Canescens
(2013-06-10)Plants are constantly exposed to pathogens and various environmental stresses, such as cold, salinity and drought. Plants normally respond rapidly to these biotic and abiotic stresses. Efficient perception of biotic and ... -
Molecular conformation and electronic structure of compounds related to amides & thioamides - a study by ab initio & semiemperical molecular orbital methods
The molecular conformation of amide derivatives is of paramount importance in understanding the factors which govern the conformations of peptides and proteins. A study of the barriers to internal rotation aids in ... -
Molecular Construction Using Carbene and Diboron Systems: Catalytic Transformation of C-C and C-Hetero Atom Bonds
The thesis presents an unconventional approach for the molecular construction using carbenes as the carbon source, and water as the hydrogen source. A gold-catalyst has been used to transfer the carbenes to effect ... -
Molecular design strategy for high EQE and low efficiency roll-off TADF organic light emitting diodes
Purely organic thermally activated delayed fluorescence (TADF) emitters are cost-effective alternatives to the rare-earth-metal-based phosphorescent emitters, offering high exciton utilization for advanced optoelectronic ... -
Molecular Determinants of Mutant Phenotypes in the CcdAB Toxin -Antitoxin System
(2018-05-29)A major challenge in biology is to understand and predict the effect of mutations on protein structure, stability and function. Chapter 1 provides a general introduction on protein sequence-structure relationships and use ... -
Molecular determinants of self-assembly of the pore forming toxin Cytolysin A
Pore forming toxins (PFTs) belong to a class of bacterial exotoxins that disrupt the biological membrane barrier by formation of nanopores. These toxins are central to the virulence of pathogens such as S. pneumoniae, ... -
Molecular dissection of Komagataella phaffii Rtg1–RtgX function and development of a glutamate-responsive protein expression platform
In Saccharomyces cerevisiae, the basic helix-loop-helix leucine zipper (bHLH-LZ) proteins Rtg1 and Rtg3 form a heterodimeric transcription factor complex that mediates the retrograde response. In Candida albicans, these ... -
Molecular Dynamics Investigations of Hybrid Nanopores for Single Molecule DNA Sequencing
High throughput methods accelerate the drug discovery, biomolecule detection and sequencing applications pipeline. Single molecule detection technique facilitates the implementation of high throughput methods by eliminating ... -
Molecular dynamics investigations of the bacterial cell envelope: Elucidating differential barriers for antimicrobials
The bacterial cell envelopes possess a complex multilayered architecture exhibiting unique properties evolved to regulate interactions with the external environment and molecules with antimicrobial properties. A molecular ... -
Molecular dynamics of the sorption and diffusion behaviour of spherical sorbates in the confined region of zeolites Y and A
The sorbate–zeolite RDFs and sorbate–zeolite energy distribution functions suggest that the sorbates are largely localized inside the cages at the lowest temperature (188 K) studied. At low temperature, the sorbate prefers ... -
Molecular dynamics simulations of O-linked Oligosaccharides from respiratory-mucus glycoproteins
Mucins belong to the class of glycoproteins that contain oligosaccharide chains in which the N-acetylgalactosamine residue is covalently linked to the hydroxyl oxygen atom in the side chain of serine or threonine on the ... -
Molecular Dynamics simulations reveal the role of membrane cholesterol in the pore forming pathway of Cytolysin A
We investigate the interactions of pore-forming toxins (PFTs) with cholesterol-rich membranes through atomistic molecular dynamics simulations. The PFT of interest is Cytolysin A (ClyA or HlyE). Cytolysin A (ClyA), an ... -
Molecular Dynamics Studies of Diffusion in Confined Regions
Diffusion of guest molecules under confinement of zeolites shows many interesting properties due to guest-host interactions. This thesis explores some of these interesting behaviours relating to the diffusion of guest ... -
Molecular Ecology of the Primitively Eusocial Wasp Ropalidia Marginata : Relatedness, Queen Succession and Population Genetics
(2018-06-08)Altruism is defined as a trait in an individual that increases some other individual’s fitness at the expense of her own. Therefore, existence of such traits in a population is an evolutionary paradox, as natural selection ... -
Molecular Expression Through Fluorescence: Studies In Probe Design And Aggregation
(2007-12-29)The present thesis entitled, "Molecular expression through fluorescence: Studies in probe design and aggregation" describes very simple bi-functional donor-acceptor poly-aromatic fluorophores that have been shown to possess ...