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Now showing items 3246-3265 of 6421
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Mechanism of RAG Regulation During Its Physiological and Pathological Functions in Lymphoid Cells
(2018-08-11)RAGs (Recombination Activating Genes) are responsible for generation of antigen receptor diversity in case of B-cells and T-cells, through the process of combinatorial joining of different V (variable), D (diversity) and ... -
Mechanism of Recycling of Ribosomes Stalled on mRNAs in Escherichia Coli
(2018-07-28)Studies reported in this thesis address the question of how pre-termination ribosomal complexes stalled during translation of mRNA are recycled. The process of recycling of the stalled ribosomes involves many translational ... -
Mechanism Of Replication Of Sesbania Mosaic Virus (SeMV)
(2015-08-12) -
Mechanism Of Ribosome Recycling In Eubacteria, And The Impact Of rRNA Methylations On Ribosome Recycling And Fidelity Of Initiation In Esherichia coli
(2009-12-09)The studies reported in this thesis address, firstly, aspects of ribosome recycling in eubacteria, and secondly, a preliminary characterization of an EFG-like locus from Mycobacterium smegmatis. A hitherto unsuspected role ... -
Mechanism Of The Benzoin Condensation And Related Studies
(2014-09-22)Chapter 1: An assessment of the mechanism of the benzoin condensation. The reaction under non-hydroxylic conditions. The generally accepted mechanism for the well known benzion condensation is unviable for the following ... -
Mechanism of the Development of Genetic Resistance to Antibiotics Mediated by three Reactive Oxygen Species in Mycobacterium smegmatis
Bacteria use different means to survive in the continued presence of antibiotics. We find that upon prolonged exposure to antibiotics, mycobacteria put up a triphasic response comprised of a logarithmic reduction of the ... -
Mechanism of β-catenin regulation by IGFBP2: Role in Glioblastoma progression
Insulin-like growth factor binding proteins (IGFBPs) were initially identified as high affinity binders of Insulin-like growth factors (IGFs). There are six IGFBPs which regulate the bioavailability and functions of IGFs ... -
Mechanisms of Dopaminergic Neurodegeneration in Parkinson's Disease
(2018-07-18)Parkinson’s disease (PD) is a debilitating movement disorder. The cardinal symptoms of PD are bradykinesia, resting tremors and rigidity. PD is characterized by degeneration of dopaminergic neurons of A9 region, substantia ... -
Mechanisms of Formation and Thermal Stabililty of Functional Nanostructures
(2018-02-22)There are many challenges in materializing the applications utilizing inorganic nanoparticles. The primary drawback is the degradation of properties due to aggregation and sintering either due to elevated temperatures or ... -
Mechanistic And Functional Insights Into Mycobacterium Bovis BCG Induced Expression Of Cyclooxygenase-2 : Implications For Immune Evasion Strategies
(2014-09-25)Mycobacteria are multifaceted pathogens capable of causing both acute disease as well as an asymptomatic latent infection. Protective immunity against pathogenic mycobacteria depends principally on cell-mediated immunity ... -
Mechanistic and Functional Insights into Mycobacterium bovis BCG Triggered PRR Signaling : Implications for Immune Subversion Strategies
Pathogenic mycobacteria are among the most dreadful pathogens known to mankind as one third of the world’s population is latently infected with M. tuberculosis, the causative agent of pulmonary tuberculosis. Host immune ... -
Mechanistic And Functional Insights Into Mycobacterium Bovis BCG Triggered TLR2 Signaling : Implications For Immune Evasion Strategies
(2015-09-04)Mycobacteria are multifaceted pathogens capable of causing both acute disease as well as an asymptomatic latent infection. Host immune responses during mycobacterial infection involve potent cell effector functions including ... -
Mechanistic And Regulatory Aspects Of The Mycobacterium Tuberculosis Dephosphocoenzyme A Kinase
(2013-09-11)The current, grim world-TB scenario, with TB being the single largest infectious disease killer, warrants a more effective approach to tackle the deadly pathogen, Mycobacterium tuberculosis. The deadly synergy of this ... -
Mechanistic And Synthetic Investigations On Carboxylic Anhydrides And Their Analogs
(2011-02-09)This thesis reports diverse synthetic and mechanistic studies in six chapters, as summarized below. Chapter 1. Revised mechanism and improved methodology for the perkin condensation.1 The generally accepted mechanism for ... -
Mechanistic Insights for Controlling Electromagnetic Interference Shielding Through Microwave Absorption in Magnetic Composites
Extensive use of electronic devices in daily communication and information technology causes high (microwave) frequency electromagnetic interference (EMI). This EMI often leads to noise, data misinterpretation or malfunctioning ... -
Mechanistic Insights into Dynamics and Thermodynamics of Biomolecular Processes: Protein Unfolding and Aggregation, DNA Nanomechanics, and Drug Delivery
Biophysics has seen unprecedented progress, applying concepts from physics to study intriguing biological phenomena. Further advances in this field require fundamental understanding of various processes at the nanoscale ... -
Mechanistic Insights Into Heat Shock Protein 90 (Hsp90) Trans-splicing in Giardia lamblia
Hsp90 gene is conserved and encoded by a single ORF with none to many cis-spliced introns across the biological kingdom. Previous studies from our lab have shown that Hsp90 gene in Giardia lamblia has a split nature having ... -
Mechanistic insights into protein stabilization and protein-protein interactions
Most amino acid substitutions in a protein either lead to partial loss of function or are near neutral. Several studies have shown the existence of second-site mutations that can rescue the defects caused by diverse loss ... -
Mechanistic Insights Into Small Molecule (Amine-Boranes, Hydrogen, Methane, Formic Acid Carbon dioxide) Activation Using Electrophilic Ru(II)-Complexes
(2017-11-09)Current fossil fuels (Coal and Petroleum) based economy is not sustainable in the long run because of its dwindling resources, and increasing concerns of climate change due to excessive carbon dioxide (CO2) emission. To ...