Browsing by Title
Now showing items 2675-2694 of 6420
-
Insights Into Oxidative Folding Of Retinol Binding Protein In The Endoplasmic Reticulum : A Study In Isolated Microsomes
(2009-04-30)The central role played by the Endoplasmic Reticulum (ER) in the correct folding and assembly of secretary and membrane proteins cannot be overstated. As the first compartment in the secretary pathway, it is responsible ... -
Insights into signalling and crosstalk in two-component signalling systems of Mycobacterium tuberculosis
Tuberculosis (TB), caused by the pathogen Mycobacterium tuberculosis (Mtb), has very recently reclaimed the position of the leading cause of deaths in humans from a single infection agent. This suggests a dire need to ... -
Insights into Structure-Property Relationships via First Principles and Machine Learning Approaches
The increasing concerns about a sustainable future demand accelerated design and development of new materials with enhanced properties. The process of material development immensely depends on the structure-to-property ... -
Insights into Substrate Specificity in Sortase Enzymes from Structural Studies on a Novel Class of Housekeeping Sortase (SrtE) Identifying Functionally Important Cis-Peptide Containing Segments in Proteins and their utility in Molecular Function Annotation
(2018-02-21)Understanding protein function is fundamental to the fields of protein engineering and drug design. While most of the previous efforts in this direction have focused on the sequence-structure-function paradigm, recent ... -
Insights into the Chemistry of Iron Complexes as Imaging and Photocytotoxic Agents
(2018-06-23)The current thesis addresses the various facets of the chemistry of photocytotoxic iron complexes including their syntheses, characterization, evaluation of the anti-proliferative activities in various cancer cell lines ... -
Insights into the conformational stability & pharmacology of peptides through side chain and backbone modification
The first part of the work presented in the thesis deals with CH-pi interaction, which is a lesser-known non-covalent interaction in proteins. We identified several CH-pi donor-acceptor pairs involving amino acids side ... -
Insights Into The Contribution Of Hfq In Salmonella Pathogenesis : Possible Role In Immune Evasion And Vaccine Development
(2014-10-07)Chapter I Introduction Salmonellae are facultative Gram-negative intracellular pathogens. Different serovars of it causes a variety of diseases in multiple hosts with different disease outcomes. Salmonella enterica serovar ... -
Insights into the Differential Cytotoxicity of Abrin and Design of a Vaccine Candidate against the Toxin
Ribosome inactivating proteins (RIPs) from plants, fungi or bacteria are extremely lethal due to their N-glycosidase activity on eukaryotic ribosomal RNA. As the name indicates, these toxins inactivate ribosomes; thereby ... -
Insights into the genesis and dynamics of the solar spicule forest: aided by simulations and laboratory experiments
The solar atmosphere is embedded with an enormous no of plasma structures with a vast range of spatial and temporal scales. Solar spicules are one of such ubiquitous features of the sun, which are present in millions ... -
Insights into the Influence of Electric Field on the Structural Evolution and its Correlation with the Properties in the Lead-based BiScO3-PbTiO3 and the Lead-free Na0.5Bi0.5TiO3 based Piezoceramics
Advanced piezoelectric ceramics are widely used as piezoelectric sensors, transducers, actuators, etc. Among the commercially viable piezoelectric systems, lead zirconate titanate, PbZr1-XTiXO3 (PZT) has dominated the ... -
Insights Into The Mechanism Of Actions Of Luteinizing Hormone And Prostaglandin F2α In The Regulation Of Corpus Luteum Function Of Monoovulatory Species
(2016-11-11)Corpus luteum (CL), a transient endocrine structure formed from the ruptured ovarian follicle after ovulation, secretes progesterone (P4) that is essential for establishment and maintenance of pregnancy in mammals. The ... -
Insights Into The Mechanism Of Polyprotein Processing Of Sesbania Mosaic Virus And Characterization Of The Polyprotein Domains
(2013-06-10)1. Viruses are obligate parasites that hijack the host cell machinery to synthesize their own gene products and for their propagation. In order to establish a successful viral infection, viruses have evolved different ... -
Insights Into The Mechanistic Details Of The M.Tuberculosis Pantothenate Kinase : The Key Regulatory Enzyme Of CoA Biosynthesis
(2013-04-26)Tuberculosis (TB), caused by Mycobacterium tuberculosis, has long been the scourge of humanity, claiming millions of lives. It is the most devastating infectious disease of the world in terms of mortality as well as morbidity ... -
Insights into the Regulation of Transcription Initiation of DNA Gyrase and Role of Transcription Factor Gre from Mycobacterium tuberculosis
Genus Mycobacterium comprises a large number of species including many pathogens such as Mycobacterium leprae, Mycobacterium abscessus and Mycobacterium tuberculosis (Mtb), the last one is the causative agent of the fatal ... -
Insights Into The Trans-Splicing Based Expression Of Heat Shock Protein 90 In Giardia Lamblia
(2016-09-14)Heat shock proteins (Hsps) are a class of molecular chaperones which were first discovered as proteins up-regulated in response to heat stress in Drosophila. Later, it was found that these set of proteins get up-regulated ... -
Insights Into Transcription-Repair Coupling Factor From Mycobacterium Tuberculosis
(2014-12-01)Introduction Nucleotide excision repair (NER) is a highly conserved pathway involved in repair of a wide variety of structurally unrelated DNA lesions. One of the well characterized NER systems is from E. coli which ... -
Insights of Evaporation Dynamics of an Interacting Linear Array of Droplet System
Manipulation of an array of sessile droplets organized in an ordered structure turns out to be of immense consequence in a wide variety of applications ranging from photonics, near field imaging and inkjet printing on one ... -
Instabilities In Supersonic Couette Flow
(2010-07-15)Compressible plane Couette flow is studied with superposed small perturbations. The steady mean flow is characterized by a non-uniform shear-rate and a varying temperature across the wall-normal direction for an appropriate ... -
Installation and Operation of Air-Sea Flux Measuring System on Board Indian Research Ships
(2018-07-04)Exchange of mass (water vapor), momentum, and energy between atmosphere andocean has profound influence on weather and climate. This exchange takes place at the air-sea interface, which is part of the marine ...