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Elucidating the Role of MsRbpA in Rifampicin Tolerance and Transcription Regulation of Mycobacterium Smegmatis
(2018-04-12)RNA polymerase binding protein A (RbpA) was first discovered as a RNA polymerase binding protein from Streptomyces. coelicolor. It was shown to cause rifampicin tolerance to RNA polymerase in vitro and leads to basal level ... -
Elucidating the role of SNARE Syntaxin 1A in regulating lysosome and melanosome function
SNAREs are transmembrane proteins that localize to specific membranes and facilitate the process of membrane/vesicle fusion. SNAREs mediate the fusion by binding with their respective cognate SNAREs. SNAREs mediate the ... -
Elucidating the Roles of Lon Protease and its Substrate, MarA, in Response to salicylate and other Compounds in Escherichia coli
(2017-11-28)Cytosolic protein degradation is crucial for cellular homeostasis as it orchestrates protein turnover by destruction of misfolded, unstable and abnormal proteins. This process has two main stages: (i) an ATP-dependent stage ... -
Elucidating the TSC2-mediated transcriptional regulation of miR-514b-3p
The PI3K-AKT-MTOR signalling axis is pivotal in regulating cell survival, proliferation, and growth. Tuberous sclerosis complex (TSC) is a well-established negative regulator of this pathway, which primarily acts by ... -
Elucidation and prediction of ion transport in battery materials: A first-principles and machine learning study
Facile ionic mobility within host frameworks is crucial to the design of high-energy-density batteries with high-power-densities, where the activation energy required for ion migration (Em) between crystallographic sites ... -
Elucidation of 17β-Estradiol (E2) Role in the Regulation of Corpus Luteum Function in Mammals : Analysis of IGFBP5 Expression during Ea-mediated Actions
(2017-12-12)Corpus luteum is a transient endocrine structure formed from the ruptured ovarian follicle. Its main function is to secrete P4, a pro-gestational hormone, essential for establishment and maintenance of pregnancy in mammals. ... -
Elucidation Of Differential Role Of A Subunit Of RNA Polymerase II, Rpb4 In General And Stress Responsive Transcription In Saccharomyces Cerevisiae
(2010-09-14)RNA polymerase II (Pol II) is the enzyme responsible for the synthesis of all mRNAs in eukaryotic cells. As the central component of the eukaryotic transcription machinery, Pol II is the final target of regulatory pathways. ... -
Elucidation of fluid dynamics of bacterial movements and transport processes in natural body fluids and its relation to pathogenesis
The transmission mechanism of respiratory diseases includes routes such as direct or indirect contact, large droplets, and airborne transmission, apart from close contact transmission, which is complex. However, the ... -
The Elucidation of the Mechanism of Meiotic Chromosome Synapsis in Saccharomyces Cerevisiae : Insights into the Function of Synaptonemal Complex, Hop1 and Red1, Proteins and the Significance of DNA Quadruplex Structures
(2017-12-03)Meiosis is a specialized type of cell division where two rounds of chromosome segregation follow a single round of DNA duplication resulting in the formation of four haploid daughter cells. Once the DNA replication is ... -
Elucidation of the Role of Nse1, a RING Domain Containing Component of Smc5/6 complex, in Maintenance of Chromosome Stability in Saccharomyces cerevisiae
(2018-05-21)Structural Maintenance of Chromosomes (SMC) proteins are a highly conserved class of proteins required for the maintenance of genome stability and regulate nearly all aspects of chromosome biology. Eukaryotes, such as the ... -
Elucidation of the structure-function relationship of the Saccharomyces cerevisiae HORMA domain-containing proteins Hop1 and Rev7
DNA-based transactions like replication, repair, recombination and transcription are central to survival, inheritance and evolution. Not surprisingly, these mechanisms are tightly regulated by a myriad of protein-protein, ... -
Embeddedness in Indian Tech Startups: An Empirical Study of Antecedents, Configuration, and Impact of Networking
Tech startups are integral to a nation’s economic progress due to their immense potential to foster innovation, job creation, exports, and investments. However, tech startups face considerable hurdles in accumulating the ... -
Embedding Networks: Node and Graph Level Representations
Graph neural networks gained significant attention for graph representation and classification in the machine learning community. For graph classification, different pooling techniques are introduced, but none of them has ... -
Embryonic Expression of Cytokines: Functional Role of Il-1β During Blastocyst Hatching
The detailed investigation on the embryo-endometrial cytokine expression, in both mouse and hamster, was carried out during the peri-hatching development and it is described in chapter 2. We hypothesize that, for a ... -
Emergence and Homeostasis of Functional Maps in Hippocampal Neurons
(2017-11-23)Systematic investigations through several experimental techniques have revealed that hippocampal pyramidal neurons express voltage gated ion channels (VGICs) with well-defined gradients along their dendritic arbor. These ... -
Emergence and Propagation of Aerodynamic Instabilities in Centrifugal Compressors with Vaned Diffusers: Effect of Solidity and Stagger
Centrifugal compressors are widely employed in turbochargers and small gas turbines due to their ability to achieve high compression per stage. These compressors consist of a rotating impeller and a static diffuser, which ... -
Emergent Phenomena from Contacts and Disorder in High Mobility Graphene
The discovery of graphene and analogous van der Waals materials offers a platform for the discovery and exploration of various novel physical phenomena. Here we study the effects of local interaction and strong localisation ... -
EMF: System Design and Challenges for Disaggregated GPUs in datacenters for Efficiency, Modularity and Flexibility
With Dennard Scaling phasing out in the mid-2000s, architectural scaling and hardware specialization take centre stage to provide performance bene fits with already stalling Moore's law. An outcome from this hardware ... -
EMI Shielding Materials Derived from PC/SAN Blends Containing Engineered Nanoparticles
(2018-07-05)In recent years, increased use of electronic devices and wireless operations resulted in unavoidable electromagnetic (EM) pollution which has a significant impact on civil and military sectors. Considering the foremost ... -
Empirical investigations of the applicability of sampling techniques for inventory valuation by computer simulation
Industrial engineering techniques such as work simplification and methods improvement have become increasingly important as industries, under the stimulus of intense competition, strive to improve operational efficiency ...