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Now showing items 1257-1276 of 8778
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Deciphering the mechanisms employed by Salmonella to mediate modulation of host endo-lysosomal machinery
Salmonella genus encompasses Gram-negative, rod-shaped, facultative anaerobic, non-sporulating, and predominantly motile enteric bacteria. It causes pathogenesis in a wide array of hosts, from cold-blooded animals to humans ... -
Deciphering the Mechanisms of AMPK Activation upon Anchorage- Deprivation
(2018-01-07)AMP-activated protein kinase (AMPK) is a key regulator of energy homeostasis in cells. It has been implicated as a therapeutic target for various metabolic diseases like type II diabetes and obesity. However, its role in ... -
Deciphering the role of DJ-1 homologs in alleviating carbonyl and oxidative stress in Arabidopsis thaliana
The present study aims to elucidate the physiological role of plant DJ-1 homologs in Arabidopsis thaliana under various abiotic stress conditions. It seeks to provide deeper insights into the diverse functions of plant ... -
Deciphering the role of host protein HuR in RNA virus life cycle and pathogenesis: Hepatitis C Virus and SARS-CoV-2 as exemplars.
Viruses pose a major threat to human health and the ongoing SARS-CoV-2 pandemic proves as the best evidence for that. Historically, RNA viruses have a major potential to cause such pandemics. They utilise RNA binding ... -
Deciphering the Role of METTL3-Dependent m6A-epitranscriptome in Glioma Stem-like Cells
The major roadblocks in treatment for GBM are resistance to therapy and recurrence of GBM cells. Regardless of various treatment strategies, the average survival of GBM patients is poor and incidence of recurrence remains ... -
Deciphering the role of miR-631 in the pathogenesis of oral squamous cell carcinoma
Oral squamous cell carcinoma (OSCC) is a malignant neoplasm originating from the epithelial cells of the oral cavity. The Asian population has the highest incidence of OSCC and despite advances in its treatment, the five-year ... -
Deciphering the role of outer membrane porins in the pathogenesis of Salmonella enterica serovar Typhimurium
Porins are highly conserved barrel-shaped proteins bound to the bacterial outer membrane and involved in the selective transport of charged molecules across the membrane. They consist of parallel and anti-parallel β sheets ... -
Deciphering the role of spermidine in Salmonella Typhimurium pathogenesis
Salmonella enterica serovar Typhimurium (S. Typhimurium) is a Gram-negative, facultative anaerobic bacterium. It infects a broad range of hosts, causing symptoms such as gastroenteritis, abdominal pain, inflammatory diarrhoea ... -
Decision Making under Uncertainty : Reinforcement Learning Algorithms and Applications in Cloud Computing, Crowdsourcing and Predictive Analytics
In this thesis, we study both theoretical and practical aspects of decision making, with a focus on reinforcement learning based methods. Reinforcement learning (RL) is a form of semi-supervised learning in which the agent ... -
Decoding determinants of selectivity in biomolecules
Molecular events demonstrate remarkable specificity amid complexity in its cellular environment. This phenomenon, termed biomolecular recognition, is fundamental to the organization and regulation of biological systems. ... -
Decoding Epigenetic Regulators in Cancer: Acetylation of HIF2A by Histone Acetyltransferase 1 (HAT1) is essential for executing hypoxia response in glioma
Gliomas are tumors of the central nervous system arising from glial cells. Based on the origin of the cell type, it can be astrocytoma, oligodendroglioma, and ependymoma. Astrocytoma is the most common type of glioma, ... -
Decoding of Attention and Behavioral State Using Local Field Potentials
Visual attention has been shown to modulate perceptual behavior and neuronal activity. Early psychophysical studies on attention showed that the subjects detected a target presented at the attended location better (i.e., ... -
Decomposition of the tensor product of Hilbert modules via the jet construction and weakly homogeneous operators
Let ½ Cm be a bounded domain and K :£!C be a sesqui-analytic function. We show that if ®,¯ È 0 be such that the functions K® and K¯, defined on £, are non-negative definite kernels, then theMm(C) valued function ... -
Decongestion Strategies for Dense Urban Airspace
With the rapid growth in the number of uncrewed aircraft systems (UAS) being deployed for on-demand delivery applications, severe congestion is anticipated in the low-altitude class-G urban airspace. Thus, there is a need ... -
Deep Convolutional and Generative Networks for Ocean Synoptic Feature Extraction and Super Resolution from Remotely Sensed Images
Accurate extraction of Synoptic Ocean Features and Downscaling of Ocean Features is crucial for climate studies and the operational forecasting of ocean systems. With the advancement of space and sensor technologies, the ... -
Deep Learning Based Channel Estimation in Wireless Communications
Deep learning techniques which employ trained neural networks to solve problems have witnessed widespread adoption in diverse fields like medicine, architecture, robotics, autonomous vehicles, wireless communications, ... -
Deep Learning for Bug Localization and Program Repair
In this thesis, we focus on the problem of program debugging and present novel deep learning based techniques for bug-localization and program repair. Deep learning techniques have been successfully applied to a variety ... -
Deep Learning for Hand-drawn Sketches: Analysis, Synthesis and Cognitive Process Models
Deep Learning-based object category understanding is an important and active area of research in Computer Vision. Most work in this area has predominantly focused on the portion of depiction spectrum consisting of ... -
Deep Learning in Computer Vision: Studies in Neuro-image Segmentation and Satellite Image Super-resolution
Single image super-resolution (SR) has been a topic of great interest in the computer vision and deep learning community and has found applications in many areas including quality enhancement of satellite images. As the ...