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Crystal Structures of Native and AdoMet Bound rRNA Methyltransferase from Sinorhizobium meliloti : Structural Insights into rRNA Recognition. Evolutionary, Structural and Functional Studies on Nucleoid-Associated Proteins HU and IHF
DNA- and RNA-binding proteins play a central role in gene regulation, which includes transcriptional control, alternative splicing, post-translational and transcriptional modifications like methylation and acetylation among ... -
Crystal Structures Of Native And Xylosaccharides-Bound Alkali Thermostable Xylanase From An Alkalophilic Bacillus SP. NG-27: Structural Insights Into Alkalophilicity. Analysis Of C-H...O Hydrogen Bonds In Helices Of Globular Proteins
(2007-11-21)Xylanases are xylan-degrading enzymes, belong to glycosyl hydrolases (GH). Xylanases from the two major families 10 (GH10) and 11 (GH11) catalyze the hydrolysis of internal β-, bonds of xylan backbone. Xylan is the second ... -
Crystal Structures of Sortase A from Streptococcus Penumoniae : Insights into Domain-Swapped Dimerization. Crystal Structures of Designed Peptides : Inhibitors of Human Islet Amyloid Polypeptide (hIAPP) Fibrillization Implicated in Type 2 Diabetes And Those Forming Self-Assembled Nanotubes
(2017-09-27)Sortases are cell-membrane associated cysteine transpeptidases that are essential for the assembly and covalent anchoring of certain surface proteins to the cell wall in Gram-positive bacteria. Thus, they play critical ... -
Crystalline Silicon Carbide Thin Films for Ultraviolet Detection
UV light detection has a lot of applications including secured satellite communication, solar and celestial observation and biological imaging. Wide bandgap materials are used to sense UV light. SiC is an excellent material ... -
Crystallization and Preliminary Structural Studies on Mycobacterium tuberculosis RuvX
The deadly pathogen Mycobacterium tuberculosis has been characterized for its virulence in immense detail. Regardless of this, the capability of M. tuberculosis to combat extreme stress conditions inside the host cell for ... -
Crystallographic and analytical ultracentrifugation studies of the E. coli acetohydroxy acid synthase I enzyme
This thesis ellucidates the mechanism of activation and regulation of AHAS I enzyme from Escherichia coli that was characterised using crystallographic and sedimentation velocity analytical ultracentrifugation studies. AHAS ... -
Crystals and molecular structures
The thesis entitled “The Crystal and Molecular Structures of Push–Pull Ethylenes” deals with the structure and conformation of eight push–pull ethylenes. Ethylenes substituted with electron?donating and electron?accepting ... -
Cues for phagosome maturation deciphered using a tuneable particulate system
Phagocytosis, an essential component of the innate immune response, is followed by the process of phagosome maturation inside the cell. Maturation ensures that the engulfed target is delivered to the acidic lysosome for ... -
Current-Mode Techniques In The Synthesis And Applications Of Analog And Multi-Valued Logic In Mixed Signal Design
(2008-10-07)The development of modern integration technologies is normally driven by the needs of digital CMOS circuit design. Rapid progress in silicon VLSI technologies has made it possible to implement multi-function and high ... -
Curvature Calculations Of The Operators In Cowen-Douglas Class
(2014-03-03)In a foundational paper “Operators Possesing an Open Set of Eigenvalues” written several decades ago, Cowen and Douglas showed that an operator T on a Hilbert space ‘H possessing an open set Ω C of eigenvalues determines ... -
Curvature Generation in Self-Assembled Fluid Membranes
The ability of thin sheets to curve into complex three-dimensional shapes underlies diverse biological processes. We study curvature generation in fluidic membranes using the model system colloidal membrane, which is ... -
Curves on Surfaces
This project report concerns the study of simple closed curves on surfaces. Specifically, we consider the question of when a closed curves on a torus can be deformed to a simple closed curve. We also consider applications ... -
Cyclic AMP In Mycobacteria Adenylyl Cyclases And Cyclic AMP Receptor Proteins
(2013-01-28)The discovery of cyclic AMP (cAMP), nearly 50 years ago by Sutherland radically altered the appreciation of metabolic regulation. Since then the presence of cAMP and its tremendous physiological impact has been demonstrated ... -
Cyclic AMP-Regulated Protein Lysine Acetylation In Mycobacteria
(2015-07-17)Tuberculosis continues to be one of the major causes of morbidity and mortality worldwide. Several mycobacterial species such as M. tuberculosis and M. africanum are responsible for causing this disease in humans. Reports ... -
Cyclic nucleotide-binding proteins in mycobacteria
Mycobacterium tuberculosis, one of the leading causes of death worldwide even today, employs the second messenger cAMP extensively for its pathogenicity and persistence. Intracellular and extracellular levels of cAMP in ... -
Cyclic peptide disulfides as conformational models; synthesis and spectroscopic studies
The study of small peptides has been motivated both by the high biological activity manifested by many peptides and their potential use as model systems for understanding polypeptide and protein structure. The development ... -
Cyclic Pursuit : Variants and Applications
(2018-02-11)The classical n-bugs problem has attracted considerable attention from researchers. This problem stems from the study of movement of a group of animals. In the context of multi- agent systems the problem has been modelled ...