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Conformational Analysis of Designed and Natural Peptides : Studies of Aromatic/Aromatic and Aromatic/Proline Interactions by NMR
(2018-04-05)
This thesis describes NMR studies which probe weak interactions between amino acid side chains in folded peptide structures. Aromatic/aromatic interactions between facing phenylalanine residues have been probed in antiparallel ...
Structural Studies on Mycobacterial Aspartic Proteinases and Adenylyl Cyclases
(2018-04-11)
Structural investigations on two mycobacterial enzymes were carried out. Tuberculosis still remains a major threat to mankind even though drugs against it have been in use for many decades. The emergence of drug resistant ...
Expanding The Horizon Of Mycobacterial Stress Response : Discovery Of A Second (P)PPGPP Synthetase In Mycobacterium Smegmatis
(2015-12-21)
The stringent response is a highly conserved physiological response mounted by bacteria under stress (Ojha and Chatterji, 2001; Magnusson et al., 2005; Srivatsan and Wang, 2007; Potrykus and Cashel, 2008). Until recently, ...
Probing Ligand Induced Perturbations In Protien Structure Networks : Physico-Chemical Insights From MD Simulations And Graph Theory
(2014-07-16)
The fidelity of biological processes and reactions, inspite of the widespread diversity, is programmed by highly specific physico-chemical principles. This underlines our basic understanding of different interesting phenomena ...
The Dynamics of Iron in Miniferritins : A Structure-Function Connection
(2017-11-23)
The DNA binding proteins under starvation (Dps) from M. smegmatis are cage-like structures which internalize iron and bind DNA. They provide resistance to the cells from free radical damage, and physically protect the DNA ...
Structural Studies on Thiolases and Thiolase-like Proteins
(2017-11-21)
The genus Mycobacterium comprises some of the most devastating pathogens that infect humans. Mycobacterium tuberculosis causes tuberculosis in humans leading to high morbidity and mortality. The disease is especially ...
Structural Studies On Three-Fold Symmetric Plant Lectins
(2013-05-21)
Lectins, multivalent carbohydrate-binding proteins of non-immune origin, have the unique ability to decode the information contained in complex carbohydrate structures of glycoproteins and glycolipids by stereo-specifically ...
Structural And Mechanistic Studies On Receptor Protein Tyrosine Phosphatases From Drosophila Melanogaster
(2013-06-20)
Protein Tyrosine Phosphatases (PTPs) initiate, modulate and terminate key cellular processes by dephosphorylating phosphotyrosine (pY) residues on signaling proteins. The coordinated action of PTPs with their cognate ...
Computer Modelling Studies On DNA Triple Helices
(2013-07-22)
Conformational Analysis And Design Of Disulfides In Antiparallel β-Sheets And Helices
(2013-08-30)
Disulfides are the primary covalent interactions within a protein molecule that connect residues which are sequentially distant. Naturally occurring disulfides enhance the stability of the protein by destabilization of ...