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Structural and Evolutionary Analyses of Signalling Proteins with Special Reference to Protein Kinases
(2018-02-27)
Cellular response to environmental changes involves a wide repertoire of complex signalling systems often resulting in up and down regulation of various genes. These mechanisms are generally conserved in a variety of ...
NMR Solution Structures of Human γC-Crystallin & the Intrinsically Disordered Viral Genome Linked Protein in the Free & Bound Form
(2018-02-14)
This thesis describes the tertiary structures and dynamic studies of two protein systems. The first is human γC -crystallin protein, which is present in the nucleus of the human eye lens and the other is the plant viral ...
Subthreshold Conductances Regulate Theta-Frequency Local Field Potentials and Spike Phase
(2018-02-21)
Local field potentials (LFPs), extracellular potentials that reflect localized electrical activity, have long been used as a window to understand the behavioural dependence and mechanistic aspects of brain physiology. A ...
Structure Determination of Proteins of Unknown Origin by a Marathon MR Protocol and Investigations on Parameters Important for Molecular Replacement Structure Solution
(2018-02-20)
Occasionally, crystallisation of proteins works in mysterious ways! One might obtain crystals of a protein of unknown identity in place of the protein for which crystallisation experiments were performed. If the investigator ...
Structural Studies on DNA Damage Inducible Protein 1 (Ddi1) of Leishmania and the Rotavirus Nonstructural Protein NSP4
(2018-01-17)
Structuraj investigations on the Ddi1 (DNA-damage inducible protein 1) of Leishmania major and on the rotavirus nonstructural protein NSP4 were carried out. Ddi1 belongs to the ubiquitin receptor family of proteins. One ...
Dissecting the C-DI-GMP Signaling Pathways : Tools and Tales
(2018-02-27)
Evaluating aerodynamic noise from aircraft engines is a design stage process, so that it conform to regulations at airports. Aerodynamic noise is also a principal source of structural vibration and internal noise in ...
Structural Studies on Bacterial Adenylosuccinate Lyase and Sesbania Mosaic Virus Protease
(2018-05-08)
The three-dimensional structures of biological macromolecules and molecular assemblies are becoming increasingly important with the changing methodologies of drug discovery. The structures aid in understanding of protein ...
Spike-Timing-Dependent Plasticity at Excitatory Synapses on the Rat Subicular Pyramidal Neurons
(2018-05-08)
The subiculum is a structure that forms a bridge between the hippocampus and the entorhinal cortex (EC) in the brain, and plays a major role in the memory consolidation process. It consists of different types of pyramidal ...
A Systems Biology Approach towards Understanding Host Response and Pathogen Adaptation in Latent Tuberculosis Infection
(2018-01-04)
Mycobacterium tuberculosis, the etiological agent of tuberculosis, has adapted with the host environment and evolved to survive in harsh conditions in the host. The pathogen has successfully evolved strategies not only to ...