Browsing Molecular Biophysics Unit (MBU) by Title
Now showing items 130-149 of 461
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Family of G-Proteins : Survey in Genomes, Structural Comparisons and Modelling(ptA)
A protein being assigned to a family does not immediately imply that it will function as a typical member of that family. It only suggests that the protein can be associated with the family based on sequence similarity. ... -
First thorough characterization of the structure, interactions and specificity of an archeal lectin with implication for TB infection
Decades long studies on plant lectins carried out in this laboratory have contributed substantially to glycobiology and helped in the initiation and development of macromolecular crystallography in India. Subsequently the ... -
Flurorescence investigation of biological systems. the alamethicin transmembrane channel and model systems
Fluorescence is a technique that has been extensively utilized in the study of systems of biological relevance due to the longevity of the excited states of many molecules, which allows for a variety of physical and chemical ... -
Folding Studies On Peanut Agglutinin : A Lectin With An Unusual Quaternary Structure
(2009-03-04)The thesis entitled “Folding studies on Peanut Agglutinin: A lectin with an unusual quaternary structure” deals with the several aspects of the folding of the tetrameric legume lectin Peanut Agglutinin ... -
Functional and structural studies of proteins involved in telomere maintenance
The linear ends of the eukaryotic chromosomes are protected by a specialized nucleoprotein complex known as telomere. Telomeres consist of telomere DNA and telomere DNA binding proteins (known as shelterin complex). The ... -
Functionally Interacting Proteins : Analyses And Prediction
(2016-05-04)Functional interaction of proteins is a broad term encompassing many different types of associations that are observed amongst proteins. It includes direct non-covalent interactions where the interacting proteins physically ... -
Further crystallographic studies on lysozyme
This thesis is concerned with further structural studies-primarily using crystallographic techniques-on the well known enzyme lysozyme. The introductory chapter briefly surveys the available X ray results, which are ... -
Further Structural Studies on Jacalin and Genomics Search for Mycobacterial and Archeal Lectins
(2017-12-03)This thesis consists of two parts. The first part is concerned with further structural and related studies of jacalin, one of the two lectins found in jack fruit seeds. The second part deals with the search of mycobacterial ... -
G-Protein Coupled Estrogen Receptor (hGPER)- Mediated Action of 17β-Estradiol on hTREK-1 Potassium Channel
TREK-1 is a two-pore domain potassium channel that contributes to maintenance of the resting membrane potential of a cell. TREK-1 is involved in several physiological and pathophysiological conditions like nociception, ... -
GABAA Receptor Mediated Phasic and Tonic Inhibition in Subicular Pyramidal Neurons
(2018-07-28)GABA is the major inhibitory neurotransmitter in the central nervous system. It binds to two types of receptors –ionotropic GABAA and metabotropic GABAB. The GABAA receptor directly gates a Clionophore that causes ... -
Garlic (Allium Sativum) Agglutinin I: Specificity, Binding And Folding Mechanism
(Indian Institute of Science, 2006-11-08)Lectins are a class of proteins that bind to carbohydrates with a high degree of specificity. They are involved in various cellular processes such as, host - pathogen interactions, targeting of proteins within cells, cell ... -
Genes involved in cell type specification and morphogenesis in Dictyostelium discoideum
Calcium-Dependent Regulation of Gene Expression and Morphogenesis in Dictyostelium discoideum Abstract and Synopsis Introduction Differentiation and morphogenesis occur in concert to ensure the development of multicellular ... -
Genetic analysis of activation and silencing of the cryptic bgl operon of Escherichia coli
Activation and Silencing of the bgl Operon in Escherichia coli: Genetic and Physiological Perspectives Abstract and Synopsis Introduction The bgl operon of E. coli is one of four genetic systems in Enterobacteriaceae for ... -
Genetic and molecular characterization of Drosophila melanogaster mutants with compromised motor and reproductive functions
Insects are among the most successful organisms, a success attributed to the evolution of flight and high reproductive capacity. Both locomotion and reproduction are regulated at multiple levels of tissue organization, ... -
Genome-Wide And Structural Analyses Of Protein Kinase Superfamily
(2010-04-12)A signal transduction process refers to chain of highly regulated biochemical steps which results in the transfer of signal in response to a stimulus in the extracellular environment to the intracellular compartments such ... -
Genome-wide and structural analyses of signalling proteins with special reference to protein kinases
The work done in the dissertation involves genome?wide sequence analysis on the Plasmodium falciparum proteins with a broad objective of understanding further the functional diversity and evolution. P. falciparum is one ... -
Genome-wide survey of plasmodium falciparum : prediction of protein function and events occuring in metabolic pathways
The work done in the dissertation involves genome-wide sequence analysis on the Plasmodium falciparum proteins with a broad objective of understanding further the functional diversity and evolution. P. falciparum is one ... -
gp120 Immunogen Design And Characterization
(2011-10-21)HIV-1 is the causative agent for AIDS and has been a major focus of research for the past two decades. Though there is a combination therapy in place known as the “Highly Active Anti-Retroviral Therapy” (HAART), its ... -
Graph theoretical studies on protein structure, folding and stability
Graph Spectral Analysis of Protein Structures: Insights into Folding, Stability, and Function Abstract and Synopsis Introduction Efficient analysis of protein 3D structures provides insights into their function, folding, ...