The aim of this study was to use human induced pluripotent stem cells (hiPSC) to understand key steps of neuronal differentiation and to model the human brain developmental disorder, primary microcephaly (MCPH). MCPH is a ...

Events in our everyday life are encoded as memories that can be consciously recollected and remembered, although our ability to retrieve the specific details associated with these events diminish with time. Such losses ...

In everyday life we make a variety of reaching movements. Most of these reaching movements have a clear objective of bringing the hand to the spatial location of the object of interest. Although we typically do not explicitly ...

Autism Spectrum Disorders (ASD) constitutes a spectrum of developmental disorders that share common phenotypes of social and communication deficits and repetitive behaviours. ASDs have many possible underlying causes ...

In response to injuries, infections or in neurodegenerative disorders, astrocytes get activated to become reactive. This phenomenon is called astrogliosis and is marked by a spectrum of changes which encompasses structural, ...

Humans and other animals form internal mental maps of the outer world in order to navigate. Hippocampal place cells and grid cells in MEC (medial entorhinal cortex) are the key components of this navigation system. However, ...

Axon growth and extension are dependent on the interaction of neurons with extracellular matrix (ECM). The interaction between cells and ECM is known as focal adhesion (FA). Vinculin is one the major proteins of FA complex ...

Amyloid Precursor Protein (APP) is a key player in Alzheimer’s disease (AD). Despite intuitive insights into differential proteolysis of APP, there is a little understanding of how the amyloidogenic machinery is distributed ...

Gaze or eye-head coordination is an ethologically and physiologically important process that directs the visual system to objects of interest. Due to its relative simplicity, it is an ideal system to study multi-effector ...

Amyloid Precursor Protein (APP) is implicated in several functions in neurons, but the altered processing of APP in synapses holds a key to understanding the onset of the molecular progression of Alzheimer’s Disease (AD). ...