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Comparative evaluation of retrograde regulatory proteins (Rtg1p, Rtg2p, and Rtg3p) of Saccharomyces cerevisiae and Pichia pastoris and identification of P. pastoris RtgXp as a novel regulator of multiple metabolic pathways
Our work demonstrates for the first time that PpRtgXp, a basic, helix-loop-helix (bHLH) protein, is a global regulator of carbon metabolism. PpRtgXp constitutively localizes inside the nucleus. Despite lacking the C-terminal ...
Mechanistic Insights Into Heat Shock Protein 90 (Hsp90) Trans-splicing in Giardia lamblia
Hsp90 gene is conserved and encoded by a single ORF with none to many cis-spliced introns across the biological kingdom. Previous studies from our lab have shown that Hsp90 gene in Giardia lamblia has a split nature having ...
Biochemical and Functional Characterization of Mycobacterium Tuberculosis Nucleoid-Associated Proteins H-NS and mIHF
(2018-08-11)
Bacteria lack nucleus and any other membrane-bound organelles. Hence all the cellular components, including proteins, DNA, RNA and other components are located within the cytoplasm. The region of the cell which encompasses ...
Mechanism of RAG Regulation During Its Physiological and Pathological Functions in Lymphoid Cells
(2018-08-11)
RAGs (Recombination Activating Genes) are responsible for generation of antigen receptor diversity in case of B-cells and T-cells, through the process of combinatorial joining of different V (variable), D (diversity) and ...
Exploring the Roles of Phase Variable HpyAII Restriction-modification System in the Human Pathogen Helicobacter pylori
Helicobacter pylori is a Gram-negative microaerophilic bacteria known to infect as much as 80% of some populations with an average morbidity range of around 50% of the world population. It has been recognized as a definitive ...
Characterization of Thymocyte Subpopulations and Mechanistic Insights during Various Modes of Thymic Atrophy
T lymphocytes along with B lymphocytes constitute the adaptive immune system, which is critical for host defence. The progenitors of T cells arise in the bone marrow and the sequential development of T cells occurs in the ...
Uncovering the Role of Mitochondrial Iron-sulfur (Fe-S) Cluster Biogenesis in Human Health and Disease
(2018-09-04)
Mitochondrial dysfunction has been implicated for a wide range of human diseases. One of the major biosynthetic processes in human mitochondria is the biogenesis of Iron-Sulfur (Fe-S) clusters which primarily involves in ...
Understanding the Sequence Dependence of NHEJ Mediated Double-strand Break Repair, and Identification of Novel DNA Ligase Inhibitors and their Potential Use as Cancer Therapeutics
Repair of DNA breaks is essential for maintenance of genomic integrity. DNA double-strand breaks (DSBs) are considered as the most harmful DNA lesions within the cells which if left unrepaired or are misrepaired, can lead ...
Understanding the Biology of Heat Shock Protein 90 in Opportunistic Fungal Pathogens
Heat shock protein 90 is one of the most abundant and evolutionary conserved class of molecular chaperones present throughout the biological kingdom. It is a specialist chaperone as its function extends beyond protein ...
Isolation, Structure Elucidation and Functional Characterization of a Novel Cytotoxic Secondary Metabolite Phomafuranone, 2-Hydroxy-2, 4-dimethyl-5-[-1-propen-1-yl]-3(2H)-furanone, from Phoma tropica an Endophytic Fungus Isolated from Mappia foetida.
Cancer has become the leading disease-related cause of death in the human population. For example, in the United States, cancer is the second leading cause of death behind cardiovascular disease, and it is projected that ...