Biochemistry (BC)
Recent Submissions
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Distinct Drivers of Type 2 Diabetes: A Systems Modeling Approach to Molecular, Genetic, and Metagenomic Insights
Type 2 Diabetes (T2D) is a complex and heterogeneous disease characterized by hyperglycemia, insulin resistance, and impaired insulin secretion. While often interrelated, hyperglycemia and insulin resistance represent ... -
Studies on the irreversible thermal denaturation of Rnase A
“STUDIES ON THE IRREVERSIBLE THERMAL DENATURATION OF RIBONUCLEASE A” SUBMITTED BY GIRISH SAHNI FOR THE Ph.D. DEGREE OF THE INDIAN INSTITUTE OF SCIENCE, BANGALORE–560012, INDIA** Processes whereby proteins and enzymes are ... -
Matabolism of phenylacetic acid by aspergillus niger
The metabolism of phenylacetic acid by Aspergillus niger was studied. The culture filtrates of A. niger grown on phenylacetate for 40 hours exhibited the presence of 2? and 3?hydroxyphenylacetic acids, 3?hydroxybenzyl ... -
Some aspects of the metabolism of mandelic acid by pseudomonas convexa, Ph.D. Thesis
The metabolism of mandelic acid (phenylglycolic acid) has been studied in detail in several bacteria, and it has been shown that the side chain of mandelic acid is first degraded, resulting in the formation of benzoic acid, ... -
Structural features of the initial active intermediate formed during acid denaturation of bovine pancreatic ribonuclease-A, Ph.D. Thesis
The present thesis deals with structural investigations of the initial products formed during acid denaturation of ribonuclease A. We have divided our observations into two sections. Section I The nature of the deamidation ... -
Indoeacetaldoxime hydro-lyase of gibberella fujikoroi
In the following pages, the work described in the preceding chapters has been summarized. The conversion of IAOX to IAN was shown to be an enzymatic process. Culture conditions for the growth of Gibberella fujikuroi ... -
Influence of vitamin B12 on the nutritive value of vegetable proteins
The work reported in this thesis relates to two main aspects: (a) To confirm and extend the finding that vitamin B?? counteracts the adverse effects of the tryptic and growth inhibitors present in raw soyabean. (b) To ... -
Unraveling the layers of DNA with the DNA-PAINT brush
DNA is both the repository of genetic information and a versatile nanoscale material whose stability and function are governed by base pairing and base-stacking interactions. Despite their fundamental role in DNA structure, ... -
Studies on the roles of Lon protease and its substrates during antibiotic resistance in Escherichia coli: modulatory effects of nitroaromatics and nitrofurantoin
Bacteria adapt to environmental stresses, including antibiotic stress, by regulating various genes and metabolic pathways. In prokaryotes, the energy-dependent protein degradation is controlled primarily by two ... -
Studies on thermo-resistant bacilli
A beginning was made in this country in the systematic study of spore‑forming bacteria capable of growing at 55°C. Ninety‑five odd isolates were obtained from sources such as soils, water from hot springs, air, dust, and ... -
Antifungal antibiotics by actinomycetes formation of champamycin - B By Streptomyces Champavatii
Presently, the chemotherapeutic treatment of the widely prevalent fungal infections in humans, animals and plants is far from satisfactory and is in marked contrast to that of bacterial diseases which are controlled successfully ... -
Understanding the physiological role of ITPK1-type inositol phosphate kinase in embryophytes
Land plants have evolved sophisticated mechanisms to adapt to phosphate (Pi) limitation, yet such regulatory networks in nonvascular bryophytes remain poorly understood. Here, we show that both male and female liverworts ... -
RNA granules and DNA damage: Exploring the role of posttranscriptional gene control upon genotoxic stress
Cells constantly encounter genotoxic stress arising from extrinsic environmental factors or intrinsic metabolic byproducts. In response, cells activate a robust DNA damage response (DDR) network to preserve genomic stability. ... -
Physico-chemical studies on hen's egg yolk lipovitellins and very low density lipoprotiens
The work described in this thesis can be broadly classified into two major sections namely, (1) Chemical studies, which describes the preparation of lipovitellins, fractionation of their protein components and comparison ... -
Studies on chemical modifications of enzymes with O-Benzoquinone. A new reaction of the Quinone with Methionine
The thesis deals mainly with studies on a new reaction of o-benzoquinone with methionine. o-Benzoquinone is a highly reactive compound which takes part in many complex reactions with proteins. Some of the functional groups ...
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