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Role of Mammalian RAD51 Paralogs in Genome Maintenance and Tumor Suppression
(2018-01-28)
My research was focused on understanding the importance of mammalian RAD51 paralogs in genome maintenance and suppression of tumorigenesis. The investigation carried out during this study has been addressed toward gaining ...
The Role of Saccharomyces Cerevisiae MRX Complex and Sae2 in Maintenance of Genome Stability
(2018-06-11)
In eukaryotes, the repair of DSBs is accomplished through two broadly defined processes: Non-Homologous End Joining (NHEJ) and Homologous Recombination (HR). The central step of HR is pairing and exchange of strands between ...
New Anticancer Secondary Metabolites from an Endophytic Fungus Chaetomium Nigricolor Isolated from Catharanthus Roseus : Structural Elucidation and Molecular Mechanism Underlying Anticancer Effects
(2018-06-13)
Cancer has become a major health problem due to its high rate of morbidity and mortality. Severe side effects associated with most of the available anticancer drugs and the development of the drug resistant cells are the ...
Molecular Insights into Lymphoid Malignancy : Role of Transcription Factor BCL11B in T-cell Leukemia Genesis and Biochemical Characterization of DNA Binding Domain of RAG1
(2018-06-29)
The lymphoid tissues consist of distinct cell subpopulations of B and T cell lineages and possess complex signaling pathways that are controlled by a myriad of molecular interactions. During the fine-tuned developmental ...
Immunomodulatory Activity of Glycodelin : Implications in Allograft Rejection
(2018-06-15)
Glycodelin, a homodimeric glycoprotein belonging to the lipocalin superfamily, is synthesised predominantly by the cells of the reproductive system of certain primates including humans. Of the four different known glycoforms ...
Role of Mycobacterium Tuberculosis RecG Helicase in DNA Repair, Recombination and in Remodelling of Stalled Replication Forks
(2018-05-14)
Tuberculosis, caused by the infection with Mycobacterium tuberculosis remained as a major global health challenge with one third of world population being infected by this pathogen.
M. tuberculosis can persist for decades ...
Structural and Biochemical Analysis of DNA Processing Protein A (DprA) from Helicobacter Pylori
(2018-05-09)
H. pylori has a panmictic population structure due to high genetic diversity. The homoplasy
index for H. pylori is 0.85 (where 0 represents a completely clonal organism and 1.0 indicates
a freely recombining organism) which ...
Structure Elucidation and Biological Evaluation of a Novel Steroidal Saponin, Cholestanol Glucoside Isolated from Saraca Asoca Enodophytic Fuungus, Lasiodiplodia Theobromae
(2018-05-16)
Although the molecular mechanisms underlying the onset and progression of cancer has been unraveled to a great extend, cancer continues to remain a leading cause of death around the world. Clinical efficacy of the existing ...
Adjunct Therapy with Curcumin for the Treatment of Malaria : Studies in a Murine Model
(2018-05-16)
Malaria accounts for 198 million cases worldwide; with a high mortality rate. 584000 deaths were reported in 2013. Malaria is a re-emerging disease globally due to drug resistance, parasite recrudescence and non-availability ...